Opioid analgesic use after cancer treatment increases risk of AEs
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Opioid analgesic use after cancer treatment increases risk of AEs Use of opioid analgesics after treatment for breast cancer appears to increase the risk of adverse events (AEs), according to findings of a study published in JAMA Network Open. US Surveillance, Epidemiology and End Results-Medicare data (2007–2016) in 38 310 female fee-for-service Medicare beneficiaries were used to evaluate the risk of opioid misuse-related AEs (opioid abuse, opioid dependence, opioid overdose or poisoning), other opioid-related AEs (cardiovascular events, falls and fractures, gastrointestinal disorders and serious infections) and all-cause hospitalisation during the year after completion of breast cancer treatment in patients 66–90 years of age who were diagnosed with breast cancer stage 0–III between 2008 and 2015. Medicare Part D prescription claims were used to determine opioid analgesic use. The rate of substance abuse-related AEs was 0.010 per 1000 patient-days, the rate of other opioid-related AEs was 0.237 per 1000 patient-days, and the rate of all-cause hospitalisation was 0.675 per 1000 patient-days. Opioid use significantly increase the risk of substance abuse-related AEs (adjusted risk ratio [aRR] 14.62; 95% CI 9.69, 22.05), other opioid-related AEs (aRR 2.50; 95% CI 2.11, 2.96) and all-cause hospitalisation (aRR 2.77; 95% CI 2.55, 3.02; all p
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