Organic Cation Transporters Integration of Physiology, Pathology, an
This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proc
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anic Cation Transporters Integration of Physiology, Pathology, and Pharmacology
Organic Cation Transporters
Giuliano Ciarimboli • Sophie Gautron Eberhard Schlatter Editors
Organic Cation Transporters Integration of Physiology, Pathology, and Pharmacology
Editors Giuliano Ciarimboli Experimental Nephrology, Medical Clinic D University of Münster Münster, Germany Eberhard Schlatter Experimental Nephrology, Medical Clinic D University of Münster Münster, Germany
Sophie Gautron French Institute of Health and Medical Research Neuroscience Institute of Biology Paris-Seine Paris, France
ISBN 978-3-319-23792-3 ISBN 978-3-319-23793-0 DOI 10.1007/978-3-319-23793-0
(eBook)
Library of Congress Control Number: 2015956344 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
This book is dedicated to the memory of Karl Julius Ullrich (1925–2010), former head of the Department of Physiology at the Max Planck Institute of Biophysics in Frankfurt am Main, Germany. Professor Ullrich was one of the founders of the renal transport physiology, especially with regard to the transport of organic anions and cations. Ullrich’s department stood out as a beacon of transport physiology. Many of his scholars were able to further increase knowledge of transport physiology. In this way, we would like to express our admiration and gratitude for his outstanding work.
Preface
Transport across the cell membrane is essential for vital processes like entry of nutrients into the intracellular compartment, delivery of cellular products to extracellular and intracellular destinations, and handling of metabolism waste products and toxic substances and is necessary to keep the intracellular milieu constant. Transport across cell membranes is mediated by a variety of diff
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