Red Cell Shape Physiology, Pathology, Ultrastructure
This monograph is a collection of invited contributions from a group of investiga tors who share a common interest in the interrelationships between the shape, struc ture, and functional characteristics of normal and pathologic erythrocytes. Most of the
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RED CELL SHAPE Physiology, Pathology, Ultrastructure
Editors Marcel Bessis Robert I~W eed Pierre F. Leblond With 147 Figures
Springer Verlag New York· Heidelberg. Berlin 1973
Proceedings of a Symposium held June 20 and 21, 1972 at the Institute of Cell Pathology, Hopital de Bicetre (as part of the scientific exchange program between N_LH., U.S.A., and LN.S.E.R.M., France)
Published as a special issue of Nouvelle Revue Fran~aise d'Hematologie, Vol. 12, N° 6, December 1972
ISBN-13: 978-3-642-88064-3 001: 10.1007/978-3-642-88062-9
© Masson
e-ISBN-13: 978-3-642-88062-9
& Cie, Editeurs, Paris 1973. Library of Congress Catalog Card Number 73-77351
Softcover reprint of the hardcover I st edition 1973 The use of general descriptive names, trade names, trade marks etc. in this publication, even if the former are not especially identified, is not to be taken as a sign that such names, as understood by the Trade Marks and Merchandise Marks Act, may accordingly be used freely by anyone.
PREFACE
This monograph is a collection of invited contributions from a group of investigators who share a common interest in the interrelationships between the shape, structure, and functional characteristics of normal and pathologic erythrocytes. Most of the authors participated in a workshop on red cell shape held in June, 1972 at the Institute of Cell Pathology, Hopital de Bicetre, Paris. We hope that these various contributions on the physiology, pathology, and ultrastructure of red cell shape will be useful and stimulating for other investigators interested in the correlation of shape and structure with the biochemistry and biophysics of the red cell. The text is divided into four sections. Section I deals with red cell shape, including the presentation of a rational descriptive nomenclature and a discussion of postsplenectomy changes. Section II deals with biochemical factors that underlie the discocyte-echinocyte (crenated) and discocyte-stomatocyte (cup-shaped) transformation. This section includes discussions of plasma factors, and of the biochemical dynamics of erythrocyte lipids and consideration of the effects of such factors as cellular ATP, calcium, aging, and various chemical agents as determinants of shape. Section III, which deals with biophysical measurements, includes studies of the deformability of cells of different shapes, descriptions of ways to define precisely the geometric dimensions of the red cell under various circumstances, and a model of membrane structure, which is proposed to account for the dimensions of red cells that undergo shape change. Finally, Section IV deals with ultrastructural studies of normal, sickled, and Heinz body-containing red cells. This section also includes a study of cells injured by antibody and complement. There are 14 full-length contributions by 20 authors, plus 4 short contributions. Each contribution presented at the symposium in Paris concludes with a discussion section. February, 1973
MARCEL BESSIS
I. WEED F. LEBLOND
ROBERT PIERRE
CONTENTS
Section I. -
Red Cell
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