Oxaliplatin
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Interstitial pneumonia: case report A 74-year-old woman developed interstitial pneumonia during treatment with oxaliplatin for rectal cancer. The woman had a history of chronic obstructive pulmonary disease and hypertension. She was diagnosed with rectal cancer, stage IIIC and underwent Hartmann’s procedure and lymph node resection. Two months after the surgery, she received an adjuvant chemotherapy with modified FOLFOX6 regimen comprising levofolinic acid [levo-leucovorin] and oxaliplatin 85 mg/m2 [route not stated] on day 1 followed by fluorouracil [5-fluorouracil]. This chemotherapy regimen was repeated every 2 weeks and 12 cycles of the chemotherapy regimen were administered. On the next day of the completion of adjuvant chemotherapy, she was hospitalised due to cough. After three days, her condition worsened and fine crackles were heard in both her lungs. The peripheral oxygen saturation (SpO2) was 77%, whereas the arterial blood gas analysis revealed a partial pressure of oxygen (PaO2) as 42.9 mm Hg and partial carbon dioxide pressure (PaCO2) of 42.9 mm Hg, on room air. In both lungs, chest X-ray revealed diffuse ground-glass opacities and the chest computed tomography scan showed severe disorder of lung architecture consisting of honeycombing. Laboratory data demonstrated WBC count of 4.4 × 103/µL, C-reactive protein level of 3.01 mg/dL, lactate dehydrogenase level of 739 U/L, Krebs von den Lungen-6 concentration of 654 U/mL, procalcitonin concentration of
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