Oxaliplatin
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Oxaliplatin Allergy: case report A 41-year-old woman developed allergy while receiving oxaliplatin for colorectal cancer [dosages and durations of therapies to reaction onset not stated]. The woman started receiving oxaliplatin; 60 minutes after the start of the fifth cycle, at a flow rate of 1.16 mg/min (0.28 mg/mL), she developed itching hives on her trunk and thighs. Intradermal tests with oxaliplatin 0.01 mg/mL were positive. The woman started receiving a desensitisation protocol with oxaliplatin at a flow rate of 0.003 mg/min (0.001 mg/mL), increased to 0.75 mg/min (0.18 mg/mL) over 6 hours. She tolerated the next two cycles, and treatment was then stopped. Six years later, oxaliplatin was restarted [dosage not stated]. In the fifth cycle, the woman developed itching hives on her neck, face and trunk at an oxaliplatin flow rate of 0.11 mg/min (0.05 mg/mL). The oxaliplatin concentration and flow rate were decreased at the first doses. She successfully received the total dosage amount in 8 hours. In the sixth cycle, she developed facial, auricular and cervical erythema at a flow rate of 0.03 mg/min (0.01 mg/mL). After decreasing the concentration and flow rate of the starting doses, oxaliplatin was administered in 9 hours. Intradermal tests were positive at 0.1–0.01 mg/mL before the first four cycles, and positive at 0.001 mg/mL before the fifth and sixth cycles [patient outcome not stated]. Author comment: "Successful desensitisation to [oxaliplatin] may be followed by an increased clinical hypersensitivity to the drug." Tovar Flores V, et al. Skin tests previous to oxaliplatin desensitisation cycles may predict their tolerance. Allergy 62 (Suppl. 83): 538 abstr. 1567, 2007 801104964 Spain
0114-9954/10/1194-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 22 Mar 2008 No. 1194
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