Oxidative stress and antioxidant defense in patients with chronic hepatitis C patients before and after pegylated interf
- PDF / 216,804 Bytes
- 6 Pages / 610 x 792 pts Page_size
- 60 Downloads / 163 Views
BioMed Central
Open Access
Research
Oxidative stress and antioxidant defense in patients with chronic hepatitis C patients before and after pegylated interferon alfa-2b plus ribavirin therapy Görenek Levent*1, Acar Ali1, Aydın Ahmet2, Eyigun Can Polat1, Çetinkaya Aytaç1, Eken Ays¸e2 and Sayal Ahmet2 Address: 1Gülhane Military Medical Academy, Department of Infectious Diseases and Clinic Microbiology, 06018, Etlik, Ankara, Turkey and 2Gülhane Military Medical Academy, Department of Toxicology, Ankara, Turkey Email: Görenek Levent* - [email protected]; Acar Ali - [email protected]; Aydın Ahmet - [email protected]; Eyigun Can Polat - [email protected]; Çetinkaya Aytaç - [email protected]; Eken Ays¸e - [email protected]; Sayal Ahmet - [email protected] * Corresponding author
Published: 20 June 2006 Journal of Translational Medicine 2006, 4:25
doi:10.1186/1479-5876-4-25
Received: 30 March 2006 Accepted: 20 June 2006
This article is available from: http://www.translational-medicine.com/content/4/1/25 © 2006 Levent et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Oxidative stress could play a role in pathogenesis of hepatitis C virus (HCV) infection. The aim of our study is to determine oxidant/antioxidant status of patients with chronic hepatitis C (CHC), and the effect of pegylated interferon alfa-2b plus ribavirin combination therapy on oxidative stress. Methods: Nineteen patients with chronic HCV infection and 28 healthy controls were included in the study. In control and patient groups, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, erythrocyte malondialdehyde (MDA) levels, erythrocyte CuZnsuperoxide dismutase (SOD), erythrocyte glutathione peroxidase (GSH-Px) activities were measured. After pegylated interferon alfa-2b and ribavirin combination therapy for 48 weeks, these parameters were measured again in the patient group. Results: Serum MDA levels increased significantly in CHC patients (n:19), before the treatment when compared with healthy subjects (n:28) 9.28 ± 1.61, 4.20 ± 1.47 nmol/ml, p < 0.001 respectively. MDA concentration decreased significantly (p < 0.001) after the treatment as well as ALT, AST activity, in erythrocytes of these patients. Average antioxidant enzymes (superoxide dismutase and glutathione peroxidase) were significantly lower in erythrocytes of patients with CHC before treatment compared with the control group (both, p < 0.001). Chronic Hepatitis C patients after pegylated interferon alfa-2b and ribavirin therapy showed values of SOD, GSH-Px were significantly higher than pretreatment levels (both, p < 0.001). Conclusion: Our results show that patients with chronic HCV infection are under the influence of oxidative stress associated with lower l
Data Loading...
