Parenteral nutrition supplements
- PDF / 170,224 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 39 Downloads / 213 Views
1
S
Liver fibrosis: 7 case reports In a retrospective study involving 53 adult patients, who underwent intestinal transplantation at a hospital in the USA between 1 January 2000 and 1 May 2014, 7 patients were described [sexes and exact ages not stated], who developed liver fibrosis during treatment with parenteral nutrition supplements. All 7 patients, who had been receiving parenteral nutrition supplements [parenteral nutrition; exact quantities not stated] 7 days a week, were scheduled to undergo intestinal transplantation. However, one of these patients was found to have stage 3 liver fibrosis on a liver biopsy. Two patients were found to have stage 1 liver fibrosis on liver biopsies performed prior to intestinal transplantation; amongst these two patients, the liver fibrosis was noted to have increased to stage 2 in one patient, and to stage 3 in the second patient during liver biopsies performed at the time of intestinal transplantation (time interval of 45 days between the two biopsies for adult with stage 3 liver fibrosis). Amongst the 2 adult patients, who had stage 3 liver fibrosis at the time of intestinal transplantation, the stage of liver fibrosis was noted to have improved to stage 2 for one patient, and to stage 1 for the second patient following the intestinal transplantation. Another adult patient, who had stage 3 liver fibrosis at the time of intestinal transplantation, was found to show improvement in liver fibrosis to stage 2 following intestinal transplantation, whereas for an adult patient, who had stage 4 liver fibrosis at the time of intestinal transplantation, the liver fibrosis remained at stage 4, with improved thickness of the fibrous septa, following intestinal transplantation. The liver fibrosis in all patients was attributed to the parenteral nutrition supplements [durations of treatments to reaction onsets not stated; not all outcomes stated]. Author comment: "[L]ong-term [parenteral nutrition] is associated with many potential complications, one of them being intestinal failure–associated liver disease (IFALD)." Huard G, et al. Prevalence, Evolution, and Risk Factors for Advanced Liver Fibrosis in Adults Undergoing Intestinal Transplantation. JPEN. Journal of Parenteral and Enteral Nutrition 42: 1195-1202, No. 7, Sep 2018. Available from: 803439550 URL: http://doi.org/10.1002/jpen.1148 - Canada
0114-9954/19/1783-0001/$14.95 Adis © 2019 Springer Nature Switzerland AG. All rights reserved
Reactions 14 Dec 2019 No. 1783
Data Loading...
