Pathogenic Yeasts
Mycological studies of yeasts are entering a new phase, with the sequencing of multiple fungal genomes informing our understanding of their ability to cause disease and interact with the host. At the same time, the ongoing use of traditional methods in ma
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H. Ruth Ashbee
l
Elaine M. Bignell
Editors
Pathogenic Yeasts
Editors Dr. H. Ruth Ashbee Mycology Reference Centre Dept. Microbiology Leeds General Infirmary United Kingdom LS1 3EX [email protected]
Dr. Elaine M. Bignell Imperial College London Div. Investigative Science South Kensington Campus London United Kingdom SW7 2AZ [email protected]
ISBN 978-3-642-03149-6 e-ISBN 978-3-642-03150-2 DOI: 10.1007/978-3-642-03150-2 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2009931050 # Springer-Verlag Berlin Heidelberg 2010 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover design: SPi Publishing Services Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Mycological studies of yeasts are entering a new phase, with the sequencing of several yeast genomes informing our understanding of their ability to cause disease and interact with the host. Parallel to this advancement, the ongoing use of traditional methods in many clinical mycology laboratories continues to provide information to diagnose and treat patients. The aim of this volume is not to provide comprehensive coverage of all aspects of pathogenic yeasts, but rather to focus on certain topics and to review the current knowledge in those areas. Each chapter has been written by relevant internationally recognised experts and is self-contained, although necessarily there is some cross referencing between chapters. Broadly speaking the content can be subdivided into four sections: Candida albicans, Cryptococcus neoformans, other pathogenic yeasts (including Malassezia, and emerging yeast pathogens) and finally clinical laboratory considerations such as diagnosis and antifungal susceptibility. Genomic advances are reviewed in the opening chapter by Butler and Fitzpatrick who summarise the state-of the-art in comparative fungal genomics and the impact that bioinformatic analysis, coupled with advanced technologies, has already had upon our understanding of fungal pathogenesis and evolution of virulence. Candida albicans, arguably the best-characterised of the pathogenic yeasts, continues to provide a beacon for fungal molecular genetics and to exemplify the power that genom
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