Pathology of Transplantation A Practical Diagnostic Approach
Many pathologists find the interpretation of biopsies and other surgical specimens from solid organ, stem cell and bone marrow transplants challenging. Pathology of Transplantation provides a practical structured and logical approach to the diagnostic int
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Pathology of Transplantation A Practical Diagnostic Approach
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Pathology of Transplantation
René P. Michel • Gerald J. Berry Editors
Pathology of Transplantation A Practical Diagnostic Approach
Editors René P. Michel Department of Pathology McGill University and McGill University Health Center Montreal, QC, Canada
Gerald J. Berry Department of Pathology Stanford University Medical Center Stanford, CA, USA
ISBN 978-3-319-29681-4 ISBN 978-3-319-29683-8 DOI 10.1007/978-3-319-29683-8
(eBook)
Library of Congress Control Number: 2016943076 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
René P. Michel: “Dedicated to my parents, to Manon and to my three sons André, Adam and Cédrik for their love, support and patience.” Gerald J. Berry: “Dedicated to my parents for conveying a lifelong love of learning and my family, Carol, Sarah, Michael, Rachel and Nicole, for the many sacrifices, love and support.”
Contents
Introduction ........................................................................................... René P. Michel and Gerald J. Berry
1
Immunobiology of Transplantation ..................................................... I. Esme Dijke
7
Immunosuppressive Drugs in Solid Organ Transplantation ............ Gerald J. Berry and Randall E. Morris
53
Heart Transplantation .......................................................................... René P. Michel and Gerald J. Berry
81
Lung Transplantation ........................................................................... 121 Gerald J. Berry Liver Transplantation ........................................................................... 173 René P. Michel and Victoria A. Marcus Pancreas Transplantation..................................................................... 265 René P. Michel In
