Genitourinary Pathology Practical Advances
This book provides a comprehensive, state-of-the art review of the genitourinary tumor pathology field and the most contemporary insights regarding specimen submission, histologic morphology, immunohistochemistry, and molecular studies useful in
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Cristina Magi-Galluzzi • Christopher G. Przybycin Editors
Genitourinary Pathology Practical Advances
Editors Cristina Magi-Galluzzi Department of Pathology Cleveland Clinic Cleveland Ohio USA
Christopher G. Przybycin Department of Pathology Cleveland Clinic Cleveland Ohio USA
ISBN 978-1-4939-2043-3 ISBN 978-1-4939-2044-0 (eBook) DOI 10.1007/978-1-4939-2044-0 Library of Congress Control Number: 2015931952 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
To my friend and charming husband Jean-Jacques Beaussart for his encouragement, forbearance, and love. Cristina Magi-Galluzzi To my wife Jennifer and my son Thomas, the two best things that ever happened to me. Christopher G. Przybycin
Preface
Our understanding of urologic pathology has dramatically evolved over time. The field has undergone significant changes, particularly since the International Society of Urological Pathology (ISUP) has led numerous conferences to standardize specimen processing, reporting, and staging of urological malignancies and has recently published guidelines and recommendations regarding best practice approaches to the use of immunohistochemistry in differential diagnosis of tumors of the bladder, prostate, kidney, and testis. Since the introduction of the Gleason grading system more than 40 years ago, many aspects of prostate cancer have changed, necessitating the modification of grading system to include new variants and subtypes of acinar adenocarcinoma of the prostate. Recently, researchers have gained new insights into the roles and function of the androgen receptors and the newly identified gene rearrangement involving the ETS family of transcription factors in prostate cancer and their clinical implications. Histological grading of bladder cancer according to the modern principles of classi
