Pattern Recognition in Bioinformatics 4th IAPR International Con

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Edited by S. Istrail, P. Pevzner, and M. Waterman Editorial Board: A. Apostolico S. Brunak M. Gelfand T. Lengauer S. Miyano G. Myers M.-F. Sagot D. Sankoff R. Shamir T. Speed M. Vingron W. Wong

Subseries of Lecture Notes in Computer Science

Visakan Kadirkamanathan Guido Sanguinetti Mark Girolami Mahesan Niranjan Josselin Noirel (Eds.)

Pattern Recognition in Bioinformatics 4th IAPR International Conference, PRIB 2009 Sheffield, UK, September 7-9, 2009 Proceedings

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Series Editors Sorin Istrail, Brown University, Providence, RI, USA Pavel Pevzner, University of California, San Diego, CA, USA Michael Waterman, University of Southern California, Los Angeles, CA, USA Volume Editors Visakan Kadirkamanathan Guido Sanguinetti Josselin Noirel University of Sheffield Mappin Street, Sheffield, S1 3JD, UK E-mail: {visakan,g.sanguinetti,j.noirel}@sheffield.ac.uk Mark Girolami University of Glasgow Glasgow, G12 8QQ, UK E-mail: [email protected] Mahesan Niranjan University of Southampton Southampton SO17 1BJ, UK E-mail: [email protected]

Library of Congress Control Number: 2009933351

CR Subject Classification (1998): J.3, I.5, F.2.2, I.2, H.3.3, H.2.8 LNCS Sublibrary: SL 8 – Bioinformatics ISSN ISBN-10 ISBN-13

0302-9743 3-642-04030-6 Springer Berlin Heidelberg New York 978-3-642-04030-6 Springer Berlin Heidelberg New York

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Preface

The Pattern Recognition in Bioinformatics (PRIB) meeting was established in 2006 under the auspices of the International Association for Pattern Recognition (IAPR) to create a focus for the development and application of pattern recognition techniques in the biological domain. PRIB’s aim to explore the full spectrum of pattern recognition application was reflected in the breadth of techniques represented in this year’s submissions and in this book. These range from image analysis for biomedical data to systems biology. We were fortunate to have invited speakers of the highest calibre delivering keynotes at the conference. These were Pierre Baldi (UC Irvine), Alvis Brazma (EMBL-EBI), Gunnar R¨atsch (MPI T¨ubingen) and Michael Unser (EPFL). We acknowledge support of the EU FP7 Network of Excellence PASCAL2 for partially funding the invited speakers. Immediately prior to the c