Pattern Recognition in Bioinformatics Third IAPR International C

This book constitutes the refereed proceedings of the International Workshop on Pattern Recognition in Bioinformatics, PRIB 2008, held in Melbourne, Australia, in October 2008. The 39 revised full papers presented were carefully reviewed and sel

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Edited by S. Istrail, P. Pevzner, and M. Waterman Editorial Board: A. Apostolico S. Brunak M. Gelfand T. Lengauer S. Miyano G. Myers M.-F. Sagot D. Sankoff R. Shamir T. Speed M. Vingron W. Wong

Subseries of Lecture Notes in Computer Science

Madhu Chetty Alioune Ngom Shandar Ahmad (Eds.)

Pattern Recognition in Bioinformatics

Third IAPR International Conference, PRIB 2008 Melbourne, Australia, October 15-17, 2008 Proceedings

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Series Editors Sorin Istrail, Brown University, Providence, RI, USA Pavel Pevzner, University of California, San Diego, CA, USA Michael Waterman, University of Southern California, Los Angeles, CA, USA Volume Editors Madhu Chetty Faculty of Information Technology Monash University, Gippsland Campus VIC-3842, Australia E-mail: [email protected] Alioune Ngom School of Computer Science University of Windsor Windsor, Ontario, Canada E-mail: [email protected] Shandar Ahmad National Institute of Biomedical Innovation Saito Asagi, Ibaraki-shi, Osaka, Japan E-mail: [email protected]

Library of Congress Control Number: Applied for

CR Subject Classification (1998): I.5, J.3, I.2, H.3, F.2.2 LNCS Sublibrary: SL 8 – Bioinformatics ISSN ISBN-10 ISBN-13

0302-9743 3-540-88434-3 Springer Berlin Heidelberg New York 978-3-540-88434-7 Springer Berlin Heidelberg New York

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com © Springer-Verlag Berlin Heidelberg 2008 Printed in Germany Typesetting: Camera-ready by author, data conversion by Scientific Publishing Services, Chennai, India Printed on acid-free paper SPIN: 12530489 06/3180 543210

Preface

In the post-genomic era, a holistic understanding of biological systems and processes, in all their complexity, is critical in comprehending nature’s choreography of life. As a result, bioinformatics involving its two main disciplines, namely, the life sciences and the computational sciences, is fast becoming a very promising multidisciplinary research field. With the ever-increasing application of largescale high-throughput technologies, such as gene or protein microarrays and mass spectrometry methods, the enormous body of information is growing rapidly. Bioinformaticians are posed with a large number of difficult problems to solve, arising not only due to the complexities in acquiring the molecular information but also due to the size and nature of the generated data sets and/or the limitations of the algorithms required for analyzing these d