Pediatric Continuous Renal Replacement Therapy Principles and Practi
This book provides a current understanding of Continuous Renal Replacement Therapies (CRRT) techniques with a focus on drug dosing in critically ill children receiving CRRT. Strategies include the role of therapeutic drug monitoring, effect of CRRT
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Principles and Practice Farahnak Assadi Fatemeh Ghane Sharbaf
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Pediatric Continuous Renal Replacement Therapy
Farahnak Assadi • Fatemeh Ghane Sharbaf
Pediatric Continuous Renal Replacement Therapy Principles and Practice
Farahnak Assadi, M.D. Professor Emeritus Department of Pediatrics Section of Nephrology Rush University Medical Center Chicago, IL, USA
Fatemeh Ghane Sharbaf, M.D. Associate Professor Department of Pediatrics Section of Nephrology Mashhad University of Medical Sciences Mashhad, Iran
ISBN 978-3-319-26201-7 ISBN 978-3-319-26202-4 DOI 10.1007/978-3-319-26202-4
(eBook)
Library of Congress Control Number: 2015959353 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
This book is dedicated to all patients for whom we care and always teach us so much.
Preface
Acute kidney injury (AKI) is a common cause of morbidity and mortality rates in critically ill patients requiring intensive care therapies (40–50 %). The incidence of AKI varies from 5 % of all hospitalized patients to 30–40 % of patients admitted to the pediatric intensive care unit. The critically ill children with AKI often have multiple organ dysfunctions and are frequently treated with several drugs including antibiotics, anticonvulsants, vasopressors, and antihypertensive and cardiovascular agents or which require appropriate dosing and interval. Despite significant improvements in the care of critically ill patients, the mortality and morbidity associated with AKI remains high (>50 %) and can lead to end-stage renal disease. Approach to the treatment of AKI patients requiring dialysis has gone under evolution with the advent of continuous renal replacement therapy (CRRT) techniques over the last two decades. Critically ill and hemodynamic instable child
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