Pediatric primary central nervous system tumors registry in Thailand under National Health Security Office schemes
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CLINICAL STUDY
Pediatric primary central nervous system tumors registry in Thailand under National Health Security Office schemes Bunchoo Pongtanakul1 · Nongnuch Sirachainan2 · Pacharapan Surapolchai3 · Pimlak Charoenkwan4 · Worawut Choeyprasert4 · Patcharee Komwilaisak5 · Su‑on Chainansamit6 · Nittaya Witsanuyothin7 · Yujinda Lertrakul8 · Piya Rujkijyanont9 · Somjai Kanjanapongkul10 · Darintr Sosothikul11 · Kleebsabai Sanpakit1 · Thirachit Chotsampancharoen12 · Somporn Wangruangsathit13 · Nintita Sripaiboonkij Thokanit14 · Sommaphun Tabjareon1 · Suradej Hongeng2 Received: 15 May 2020 / Accepted: 11 July 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background Few epidemiological studies of pediatric central nervous system (CNS) tumors have been performed using data from Southeast Asian national registries. Therefore, we aimed to examine data on CNS tumors from the first national childhood CNS tumor registry in Thailand. Methods Newly diagnosed children with benign and malignant primary CNS tumors from 20 nationwide hospitals were included. Two eras in the Thai registry were studied to compare national protocol effectiveness, including 2003–2005 (before establishment of a pediatric CNS tumor protocol) and 2011–2012 (post-establishment). Results The first study period had 300 patients with an incidence of 7.5/1,000,000 person-years and the second had 168 patients with an incidence of 13.24/1,000,000 person-years. The three most common tumors were gliomas, medulloblastoma/ primitive neuroectodermal tumor (PNET), and germ cell tumors. The most common tumor site was the cerebellum, followed by the brainstem and pineal region. Five- and 10-year overall survival (OS) rates were 46.62% (95% confidence interval [CI] 40.85–52.18) and 41.78% (95% CI 36.11–47.34), respectively, for the first period. The second period had a 5-year OS of 64.75% (95% CI 56.70–71.68). OS rates for gliomas, germ cell tumors, medulloblastoma/PNET, and ependymomas were better in the second period than in the first period. Conclusions The incidence of primary childhood CNS tumors in our study is lower compared with other reports. Improvement of OS in the second study period might be because of establishment of the Thai Pediatric Oncology Group, and national protocols for childhood CNS tumors. Keywords Asia · CNS tumor · Developing country · Pediatrics · Registry · Thailand
Introduction Pediatric CNS tumors are the second or third most common childhood malignancy. These tumors are the most common solid tumors in children, comprising nearly 15–25% of all childhood neoplasms [1, 2]. These CNS tumors are a significant source of cancer-related morbidity and mortality with a Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11060-020-03582-w) contains supplementary material, which is available to authorized users. * Suradej Hongeng [email protected] Extended author information available on the last page of the article
high cost of treatment. The inciden
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