Peptide Arrays with a Chip
Today, lithographic methods enable combinatorial synthesis of >50,000 oligonucleotides per cm2, an advance that has revolutionized the whole field of genomics. A similar development is expected for the field of proteomics, provided that affordable, ver
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Molecular Biology™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For other titles published in this series, go to www.springer.com/series/7651
Small Molecule Microarrays Methods and Protocols Edited by
Mahesh Uttamchandani Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore
Shao Q. Yao Departments of Chemistry and Biological Sciences, Faculty of Science, National University of Singapore, Singapore
Editors Dr. Mahesh Uttamchandani Defence Medical and Environmental Research Institute DSO National Laboratories 27 Medical Drive, #12-01, Singapore 117510 [email protected]
Dr. Shao Q.Yao Department of Chemistry and Biological Sciences Faculty of Science National University of Singapore Singapore [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-60761-844-7 e-ISBN 978-1-60761-845-4 DOI 10.1007/978-1-60761-845-4 Library of Congress Control Number: 2010936183 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface Small Molecule Microarrays (SMMs): Methods and Protocols showcase a cornucopia of ways in which SMM technology may be deployed for multiplexed screening and profiling. SMMs were introduced just a decade ago in 1999 and, within a short space of time, have already established themselves as a vibrant, next generation platform for high-throughput screening. Significant developments, over the last decade, have equipped practitioners with an array of synthetic options, immobilization chemistries, assay modalities, and data processing schemes, thereby propelling the SMM platform to exciting new heights. Many of the scientists personally responsible for the success of these research endeavors have contributed chapters to this volume. As a result, the richness and diversity of this collection offers unique learning opportunities, both in fueling the development of new ideas and applications, as well as in tailoring proven solutions for different sets of libraries and microarray formats. Proven approaches, however, rarely work at the first attempt. Moreover, microarrays are notorious for the technical challenges they pose. It is to address these shortcom
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