Lab-on-a-Chip Biosensors
In the previous chapter, we learned that both optical and electrochemical immunosensors can be implemented in a microchannel to facilitate rinsing steps that are labor-intensive and require a skilled operator. In fact, there have been attempts to provide
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Lab-on-a-Chip Biosensors
In the previous chapter, we learned that both optical and electrochemical immunosensors can be implemented in a microchannel to facilitate rinsing steps that are labor-intensive and require a skilled operator. In fact, there have been attempts to provide a higher level of automation and to increase ease of use immunosensors (and certainly other biosensors as well), through fabricating more complicated microchannels. These attempts have usually been achieved by utilizing a concept known as lab-on-a-chip.
13.1
What Is Lab-on-a-Chip
A lab-on-a-chip (LOC) is a device that integrates several laboratory functions onto a small platform, typically only millimeters or centimeters in size. It is essentially a network of channels and wells that are etched onto silicon or polymer substrates to build miniature laboratories (Fig. 13.1). LOCs normally involve the handling of very small fluid volumes, usually on the mL or nL scale, and of very small depth and width of channels,
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