Peroxo Complexes of Th(IV) and Zr(IV) Ions Containing Aspartic Acid and Amine Bases as Potential Biological Agents
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eroxo Complexes of Th(IV) and Zr(IV) Ions Containing Aspartic Acid and Amine Bases as Potential Biological Agents N. A. Bitua, S. Hossainb, N. Islamc, A. Kadera, M. S. Islama, M. M. Haquea, F. Hossena, A. Asrafa, R. K. Mohapatrad, and Kudrat-E-Zahana,* a Department
of Chemistry, University of Rajshahi, Rajshahi, 6205 Bangladesh of Chemistry, Begum Rokeya University, Rangpur, 5400 Bangladesh c Chemistry Discipline, Khulna University, Khulna, 9208 Bangladesh d Department of Chemistry, Government College of Engineering, Keonjhar, Odisha, 758002 India *e-mail: [email protected] b Department
Received June 20, 2020; revised August 6, 2020; accepted August 10, 2020
Abstract—Eight new peroxo complexes of the type [MO(O2)(Asp)L] have been synthesized and characterized by conductivity, magnetic moments, UV-Vis, IR, ESI-MS and 1H NMR spectra, TLC, and elemental analyses [M = Th(IV) and Zr(IV), Asp= deprotonated aspartic acid, L = quinoline, isoquinoline, 8-hydroxyquinoline, and 1,10-phenanthroline]. IR spectra indicate that the ligands coordinate to the metal ions via nitrogen of the amino group of aspartic acid and heterocyclic amines, oxygen of the carboxylate group of deprotonated aspartic acid and the peroxo group (O–O). ESI-MS spectral data and magnetic moment values coupled with electronic spectral data suggest an octahedral geometry for all the complexes. The molar conductance values indicate that all the complexes behave as 1 : 2 electrolytes except complexes of 8-hydroxyquinoline that behaves as 1 : 3 electrolytes. Antibacterial activity of the complexes has been tested against four pathogenic bacteria, two Gram-positive Staphylococcus aureus and Bacillus subtilis and two Gram-negative Escherichia coli and Shigella dysenteriae using Kanamycin (K-30) as a standard. The MIC values for complexes hve been measured. Antifungal activity of the complexes has been tested against four pathogenic fungi Aspergillus flavus, Penicillium species, Candida species, and Aspergillus niger using Fluconazole-50 as a standard. The complexes K2[ThO(O2)(Asp)(IQ)] and K2[ZrO(O2)(Asp)(Q)] demonstrate the highest antibacterial activity, and K2[ZrO(O2)(Asp)(1,10-Phen)] exhibits the highest antifungal activity against all the tested pathogens. Keywords: peroxo complexes, aspartic acid, heterocyclic amines, antibacterial activity, MIC, antifungal activity
DOI: 10.1134/S1070363220080253 INTRODUCTION Peroxo complexes of transition metals are sources of active oxygen, and many complexes act as catalytic oxidants for organic and inorganic substrates [1, 2]. Reactivity of the peroxo complexes depends on the nature of the other auxiliary ligands involved. Peroxo complexes containing monodentate and bidentate auxiliary ligands can undergo oxygen transfer reactions [3, 4]. Those containing tridentate and quadridentate ligands are inert towards oxidation. Based on the above, the present study has been devoted to synthesis, characterization and tests of antimicrobial activity of some novel mixed ligand complexes of Th(IV) and Zr(IV) ions with asparti
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