Phenobarbital and carbamazepine: similar behavioural side effects
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Phenobarbital and carbamazepine: similar behavioural side effects The use of phenobarbital does not appear to be associated with an excess in behavioural side effects in children with epilepsy, compared with carbamazepine, according to researchers from Bangladesh. They conducted a double-blind trial involving 108 eligible children (aged 2–15 years) with tonic-clonic or partial seizures who were randomised to receive phenobarbital (n = 54) or carbamazepine.* Behaviour was assessed using the Bayley scale, Richman behavioural assessment questionnaire, and Conners’ short questionnaire for parents. At 1 year, 59 children had no change, 16 had improvement, and ten experienced excessive akathisia and hyperactivity; of ten children, four and six were in the phenobarbital or carbamazepine groups, respectively. No significant difference in behavioural outcomes was observed between the two groups. * Starting and initial maintenance doses were 5 and 16 mg/kg/day for carbamazepine, respectively, and 1.5 and 3 mg/kg/day for phenobarbital, respectively, taken in two divided doses daily. Banu SH, et al. Side effects of phenobarbital and carbamazepine in childhood epilepsy: randomised controlled trial. BMJ [Online] 334: 1207-1210, No. 7605, 9 801034403 Jun 2007
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Reactions 9 Dec 2006 No. 1131
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