Physical, Emotional, and Psychosocial Challenges Associated with Daily Dosing of HIV Medications and Their Impact on Ind
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ORIGINAL PAPER
Physical, Emotional, and Psychosocial Challenges Associated with Daily Dosing of HIV Medications and Their Impact on Indicators of Quality of Life: Findings from the Positive Perspectives Study Patricia de los Rios1 · Chinyere Okoli2 · Erika Castellanos3 · Brent Allan4 · Benjamin Young5 · Garry Brough6 · Marvelous Muchenje1 · Anton Eremin7 · Giulio Maria Corbelli8 · Marta McBritton9 · W. David Hardy10 · Nicolas Van de Velde2 Accepted: 30 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract To assess challenges with daily oral antiretroviral therapy (ART), we analyzed data for 2389 participants in the 2019 Positive Perspectives survey of people living with HIV in 25 countries. ART-related challenges reported included difficulty swallowing pills (33.1% [790/2389]); stress from daily dosing routine (33.3% [795/2389]); bad memories from daily intake of HIV medication (35.1%[839/2389]), and concern “that having to take pills every day means a greater chance of revealing my HIV status to others” (37.9% [906/2389]). Individuals who felt empowered by daily oral dosing [“taking my pill(s) every day reassures me that my HIV is being kept under control”] had 69% higher odds of optimal overall health (AOR 1.69, 95% CI 1.40–2.04). Conversely, odds of optimal overall health were lower among those who felt daily pill intake “limits my day-to-day life” (AOR 0.53, 95% CI 0.44–0.64). These findings show that there is need for increased flexibility of ART delivery to meet diverse patient needs. Keywords Stigma · Difficulty swallowing · Quality of life · Privacy · Antiretrovirals
Introduction Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10461-020-03055-1) contains supplementary material, which is available to authorized users. * Patricia de los Rios [email protected] 1
ViiV Healthcare, Quebec, Canada
2
ViiV Healthcare, Brentford, Middlesex, UK
3
Global Action for Trans* Equality (GATE), Belize City, Belize
4
International Council of AIDS Service Organizations (ICASO), Toronto, Canada
5
ViiV Healthcare, Research Triangle Park, NC, USA
6
Positively UK, 345 City Road, London, UK
7
AIDS Center Foundation, Moscow, Russia
8
European AIDS Treatment Group, Rome, Lazio, Italy
9
Instituto Cultural Barong, São Paulo, Brazil
10
Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Globally, there are an estimated 37.9 million people living with HIV/AIDS (PLHIV) [1]. PLHIV report a myriad of emotional and psychosocial problems such as coping with being diagnosed with the disease and acceptance of it, sharing their diagnosis with others, decision making regarding treatment, sexual activity and desires of parenthood, seeking social/emotional support, and workplace-related challenges [2–8]. Substance abuse as a coping mechanism may further worsen psychological and mental health problems among PLHIV [9–11]. Stigma among PLHIV significantly causes
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