Phytochemicals and endothelial dysfunction: recent advances and perspectives
- PDF / 1,188,442 Bytes
- 39 Pages / 547.087 x 737.008 pts Page_size
- 48 Downloads / 210 Views
(0123456789().,-volV) ( 01234567 89().,-volV)
Phytochemicals and endothelial dysfunction: recent advances and perspectives Alexandra Bujor . Anca Miron . Adriana Trifan . Simon Vlad Luca . Elvira Gille . Sorin-Dan Miron . Ana Clara Aprotosoaie
Received: 5 July 2020 / Accepted: 16 October 2020 Ó Springer Nature B.V. 2020
Abstract Endothelial dysfunction (impaired vasodilation, prothrombotic, proinflammatory and prooxidant states) is involved in the development of cardiovascular diseases (atherosclerosis, hypertension, heart failure, stroke) and vascular complications of diabetes mellitus. Reduced production of A. Bujor Department of Pharmaceutical Technology, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700115 Iasi, Romania A. Miron (&) A. Trifan S. V. Luca A. C. Aprotosoaie Department of Pharmacognosy, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700115 Iasi, Romania e-mail: [email protected]; [email protected] S. V. Luca Biothermodynamics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Maximus-von-Imhof-Forum 2, 85354 Freising, Germany E. Gille National Institute of Research and Development for Biological Sciences Bucuresti/Stejarul Biological Research Centre, 6 Alexandru cel Bun Street, 610004 Piatra Neamt, Romania S.-D. Miron Department of Biophysics and Medical Physics, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700115 Iasi, Romania
endothelium-derived relaxing factors, increased release of endothelium-derived constricting factors, prothrombotic molecules and inflammatory mediators, upregulation of growth factors and adhesion molecules play a crucial role in the development and progression of endothelial dysfunction. Phytochemicals belonging to different chemical classes (alkaloids, flavonoids, isoflavonoids, phenolic acids, terpenoids) were reported to prevent and/or reverse endothelial dysfunction in different experimental models. Many of them showed a multitarget activity which is a great advantage in tackling endothelial dysfunction and thereby, they may serve as lead compounds for novel drug development. Salvianolic acid B, caffeic, chlorogenic, ferulic and rosmarinic acids, resveratrol, luteolin are only some examples of phytochemicals modulating multiple mechanisms associated with endothelial dysfunction. Obviously, extensive clinical trials are needed to confirm the efficacy of phytochemicals in improving endothelial function and also their safety. In addition, formulation strategies to enhance bioavailability and afford an endotheliumtargeted delivery should be explored. Keywords Endothelium Nitric oxide Caffeic acid Salvianolic acid Rosmarinic acid Genistein Abbreviations ACE Angiotensin I-converting enzyme Ach Acetylcholine
123
Phytochem Rev
ADMA AGEs Akt AMPK Ang II AP-1 ApoE-/ARE ASS AT1 ATP BAEC Bcl-2 BH4 BMEC BMP4 cAMP cGMP CHOP CMEC cNOS COX-2 CRP DDA DHFR DOCA D
Data Loading...
