Endothelial Dysfunction and Inflammation
Endothelial dysfunction is broadly defined as a disruption of the balance between vasoactive mediators and a propensity towards an inflammatory state. This volume provides an overview of the fields of endothelial dysfunction and inflammation through the d
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Endothelial Dysfunction and Inflammation
Shauna M. Dauphinee Aly Karsan Editors
Progress in Inflammation Research
Series Editor Prof. Michael J. Parnham, PhD Director of Science MediMlijeko d.o.o. 10000 Zagreb Croatia
Advisory Board G. Z. Feuerstein (Wyeth Research, Collegeville, PA, USA) M. Pairet (Boehringer Ingelheim Pharma KG, Biberach a. d. Riss, Germany) W. van Eden (Universiteit Utrecht, Utrecht, The Netherlands)
Forthcoming titles: Muscle, Fat and Inflammation: Sustaining a Healthy Body Composition, S.A. Stimpson, B. Han, A.N. Billin (Editors), 2011 The Inflammasomes, I. Couillin, V. Petrilli, F. Martinon (Editors), 2011 Proteases and their Receptors in Inflammation, N. Vergnolle, M. Chignard (Editors), 2011 Antimicrobial Peptides and Innate Immunity, P.S. Hiemstra, S.A.J. Zaat (Editors), 2011 (Already published titles see last page.)
Endothelial Dysfunction and Inflammation
Shauna M. Dauphinee Aly Karsan Editors
Birkhäuser
Editors Shauna M. Dauphinee Aly Karsan BC Cancer Research Centre 675 West 10th Avenue Vancouver BC, V5Z 1L3 Canada
Library of Congress Control Number: 2010928044
Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the internet at http://dnb.ddb.de
ISBN 978-3-0346-0167-2 The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use. This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained. © 2010 Springer Basel AG P.O. Box 133, CH-4010 Basel, Switzerland Part of Springer Science+Business Media Printed on acid-free paper produced from chlorine-free pulp. TCF d Cover design: Markus Etterich, Basel Cover illustration: Early atherosclerotic lesion in LDL receptor deficient mice. With friendly permission by Myron Cybulsky. Printed in Germany ISBN 978-3-0346-0167-2 e-ISBN 978-3-0346-0168-9 987654321 www.birkhauser.ch
Contents
List of contributors Preface
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vii
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xi
John M. Harlan Endothelial activation and dysfunction in sepsis
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1
Grietje Molema Heterogeneity in responses of microvascular endothelial cells during inflammation . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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