Platelet Rich Fibrin Membrane Grafting After Laser Excision for Oral Mucosal Lesions
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ORIGINAL ARTICLE
Platelet Rich Fibrin Membrane Grafting After Laser Excision for Oral Mucosal Lesions Nishant Kumar Tewari1 • Vivek Kumar2
•
Neha Choubey3 • Sushmita Tiwari4
Received: 6 September 2020 / Accepted: 12 October 2020 Association of Otolaryngologists of India 2020
Abstract Platelet rich fibrin (PRF) is a novel surgical biomaterial which has shown immense healing and regenerative potential with diverse clinical applications. Surgical excision is a routinely employed treatment modality for mucosal oral lesions with or without grafting or repair of the base of the wound. We proposed a hypothesis that covering of the base of excised lesion with this platelet rich fibrin membrane can accelerate the rate of physiological healing process and regeneration. To evaluate the role, efficacy, advantages and adverse effects if any, of placement of PRF membrane grafts over surgical excision sites of oral mucosal lesions. Platelet rich fibrin membrane graft was prepared as per recommendation and established protocols. Patients were selected for surgical excision of localized, superficial oral mucosal lesions after meticulous clinical and radiological considerations and informed consent was taken. After laser excision with safe margins, the base of wound was covered with PRF & Vivek Kumar [email protected] Nishant Kumar Tewari [email protected] Neha Choubey [email protected] Sushmita Tiwari [email protected] 1
Department of Oral and Maxillofacial Surgery, NMCH, Patna, India
2
Department of ENT, PMCH, Ashok Rajpath, Patna 800004, India
3
Department of Biochemistry, NMCH, Patna, India
4
Kiran Dental and Maxillofacial Surgery Centre Patna, Patna, India
membrane graft, stitched in place by 3-0 vicryl sutures. The operated site was clinically evaluated at regular intervals and a healing score was calculated and statistically tabulated on the basis of various parameters of healing. A total of 34 patients were included in the study with a male preponderance (21 males and 13 females). Satisfactory and clinically acceptable wound healing was observed in most of the patient with minimal morbidities. Surgical site demonstrated good healing score and clinically complete healing with good epithelialisation was achieved in all patients. Platelet rich fibrin membrane is an effective grafting biomaterial after excision of oral mucosal lesions as it enhances the rate of healing with minimal complications. We recommend further multicentre studies with higher sample size to explore its utility and clinical applications in different avenues of oral and head neck surgery. Keywords Platelet rich fibrin Biomaterial Platelet derived growth factor
Introduction Wound healing is a highly coordinated sequence of biochemical, physiological, cellular and molecular responses involving a cascade of events to restore tissue integrity and functional capacity after injury. Advancements in the clinical understanding of pathophysiology of wounds have commanded significant biomedical innovations. Various biomater
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