Polycystic kidney disease concurrent with feline parvovirus and bacterial infections in domestic shorthair cat: a case r
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CASE REPORT
Polycystic kidney disease concurrent with feline parvovirus and bacterial infections in domestic shorthair cat: a case report Pauline Poh Ling Sim Lam 1 & Mohd Farhan Hanif Reduan 1 & Sabri Jasni 1 & Rumaizi Shaari 2 & Nurshahirah Shaharulnizim 2 & Muhammad Luqman Nordin 2 & Aziz Abd Rahman 1 & Nadiah Syuhada Roslan 2 Received: 19 April 2020 / Accepted: 22 September 2020 # Springer-Verlag London Ltd., part of Springer Nature 2020
Abstract Feline polycystic kidney disease (PKD) is an inherited disorder caused by the mutation of PKD1 gene that eventually lead to the development of chronic kidney disease. The latter condition causes hypertension and eventually progress into congestive heart failure. Feline parvovirus (FPV) is a highly contagious and often fatal disease infecting cats and other members of Felidae. An 8-month-old female domestic shorthair cat was presented with complaint of wound dehiscence a day after ovarian hysterectomy procedure. The wound at the suture site appeared necrotic, purulent with foul smell. The cat was found to have diarrhoea during the fixation of suture breakdown and, later, was tested positive with parvovirus infection. Complete blood count revealed anaemia, neutrophilia, lymphopenia and thrombocytosis. Biochemistry profiles showed hypoproteinaemia and elevated of urea and creatinine. The cat was hospitalised, and symptomatic treatments were given. During hospitalisation, the cat showed symptoms of polydipsia and polyuria and found dead 2 days later. Post-mortem findings demonstrated the cat had oral ulceration, thoracic effusion, fibrinopleuropneumonia, pericardial effusion, left ventricular hypertrophy and right ventricular dilation, chronic passive liver congestion, mesenteric lymphadenomegaly, intestinal haemorrhage, adrenomegaly and polycystic kidney. Histopathological evaluation revealed fibrinous pleuropneumonia, pulmonary atelectasis, emphysema and oedema, hypertrophic cardiomyopathy, hepatic necrosis, splenic necrosis, intestinal necrosis, renal necrosis and renal polycystic. Staphylococcus aureus and Escherichia coli were isolated from bronchus swab and intestinal segment, respectively. Polymerase chain reaction (PCR) revealed parvovirus infection. The cat was definitely diagnosed with polycystic kidney disease concurrent with parvoviral and secondary bacterial infections. Keywords Chronic kidney disease . Congestive heart failure . Feline parvovirus . Polycystic kidney disease
Introduction Polycystic kidney disease (PKD) is an inherited genetic disease in cats and has a high prevalence in Persian cats and Persian-related cats and infrequent in mixed breeds (Volta et al. 2010). Purebred cat has a prevalence of 20% occurrence while Persian-type breed constitutes of the remaining 80%, making PKD a commonly found inherited disease for cats
* Mohd Farhan Hanif Reduan [email protected] 1
Department of Para Clinical Studies, Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Pengkalan Chepa, 16100 Kota Bharu, Kelantan, Malaysia
2
Department of Clini
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