Potential advantages of cell administration on the inflammatory response compared to standard ACE inhibitor treatment in
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Potential advantages of cell administration on the inflammatory response compared to standard ACE inhibitor treatment in experimental myocardial infarction Michele M Ciulla*1,2, Elisa Montelatici2,3, Stefano Ferrero4, Paola Braidotti4, Roberta Paliotti1,2, Giuseppe Annoni1,2, Elisa De Camilli4, Giuseppe Busca1,2, Luisa Chiappa1,2, Paolo Rebulla2, Fabio Magrini1,2 and Lorenza Lazzari2,3 Address: 1Istituto di Medicina Cardiovascolare, Centro di Fisiologia Clinica e Ipertensione, University of Milan, Italy, 2Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS, Milan, Italy, 3Cell Factory "Franco Calori", Milan, Italy and 4II Cattedra di Anatomia Patologica, University of Milan, DMCO A.O. San Paolo, Milan, Italy Email: Michele M Ciulla* - [email protected]; Elisa Montelatici - [email protected]; Stefano Ferrero - [email protected]; Paola Braidotti - [email protected]; Roberta Paliotti - [email protected]; Giuseppe Annoni - [email protected]; Elisa De Camilli - [email protected]; Giuseppe Busca - [email protected]; Luisa Chiappa - [email protected]; Paolo Rebulla - [email protected]; Fabio Magrini - [email protected]; Lorenza Lazzari - [email protected] * Corresponding author
Published: 12 June 2008 Journal of Translational Medicine 2008, 6:30
doi:10.1186/1479-5876-6-30
Received: 3 June 2008 Accepted: 12 June 2008
This article is available from: http://www.translational-medicine.com/content/6/1/30 © 2008 Ciulla et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Bone Marrow (BM) progenitor cells can target the site of myocardial injury, contributing to tissue repair by neovascolarization and/or by a possible direct paracrine effect on the inflammatory cascade. Angiotensin Converting Enzyme inhibitors (ACE-I) are effective in reducing mortality and preventing left ventricular (LV) function deterioration after myocardial infarction. Methods: We investigated the short term effects of BM mononuclear cells (BMMNCs) therapy on the pro-inflammatory cytokines (pro-CKs) and on LV remodelling and compared these effects over a standard ACE-I therapy in a rat model of myocardial cryodamage. Forty two adult inbread Fisher-F344 rats were randomized into three groups: untreated (UT; n = 12), pharmacological therapy (ACE-I; n = 14, receiving quinapril), and cellular therapy (BMMNCs; n = 16, receiving BMMNCs infusion). Rats underwent to a standard echocardiogram in the acute setting and 14 days after the damage, before the sacrifice. Pro-CKs analysis (interleukin (IL)1β, IL-6, tumor necrosis factor (TNF)α was performed (multiplex proteome arrays) on blood samples obtained by direct aorta puncture before the sacrifice; a control group of
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