Precision Stroke Animal Models: the Permanent MCAO Model Should Be the Primary Model, Not Transient MCAO
- PDF / 986,830 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 42 Downloads / 165 Views
COMMENTARY
Precision Stroke Animal Models: the Permanent MCAO Model Should Be the Primary Model, Not Transient MCAO Devin W. McBride 1 & John H. Zhang 1,2,3
Received: 29 May 2017 / Revised: 28 June 2017 / Accepted: 5 July 2017 # Springer Science+Business Media, LLC 2017
Abstract An argument for preclinical stroke research to make more use of the permanent middle cerebral artery occlusion (MCAO) model, rather than transient MCAO, is presented. Despite STAIR recommending permanent MCAO as the primary model, preclinical stroke research has not been listened. In 2012, Hossmann reported that 64% of the treatment studies for MCAO used prompt transient MCAO models and only 36% of the studies used permanent MCAO or gradual transient MCAO (i.e., embolic stroke model). Then, in 2014 and 2015, 88% of published basic science studies on large vessel occlusion used the transient MCAO model. However, this model only represents 2.5–11.3% of large vessel stroke patients. Therefore, the transient MCAO model, which mimics stroke with reperfusion, does not accurately reflect the majority of clinical stroke cases. Thus, once again, the argument for studying permanent MCAO as a primary model is made and supported. Keywords Animal models . Ischemia . Middle cerebral artery occlusion . Reperfusion . Stroke
Electronic supplementary material The online version of this article (doi:10.1007/s12975-017-0554-2) contains supplementary material, which is available to authorized users. * John H. Zhang [email protected] 1
Department of Physiology & Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
2
Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
3
Department of Anesthesiology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
Introduction to the Disparity Between the Usage of Ischemic Stroke Animals Models and the Prevalence of Clinical Stroke Subtypes The most widely used animal model of stroke, transient middle cerebral artery occlusion, was utilized in 88% of the experimental studies in 2014 and 2015 (see BMimicking Clinical Stroke Pathology with Animal Models^ in this article). Despite the recommendations by STAIR [1] and others in stroke research [2–4], we are still employing the transient middle cerebral artery occlusion model more often than is observed clinically. Since the original STAIR meeting [1], a number of publications have presented basic science arguments against the use of the transient middle cerebral artery occlusion model as the primary model for cerebral ischemia [2–4]. In this perspective, we will renew the discussion for minimizing our use of the transient middle cerebral artery occlusion animal model, but we will base the argument on the clinical presentations of large vessel stroke. Also discussed are the future directions for precision animal modeling of stroke.
Large Vessel Stroke There are 650,000 US ischemic stroke patients annually, with 40–50% of them (~300,000) experiencing stroke due to large vessel occlusion
Data Loading...
