Pregabalin
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Drug abuse, overdose and related complications: case report A 23-year-old woman experienced unconsciousness, involuntary movements of arms, dizziness, lethargy, noncooperativeness and myoclonic seizures following pregabalin abuse in an overdose. The woman presented to emergency department with involuntary movements of arms and unconsciousness. During investigation, from a detailed anamnesis from her colleagues, it was clear that she had administered nasal inhalation of 10-15 capsules of pregabalin 300mg for recreational purpose for the first time. Following 2–3 hours of administration, she noted involuntary movements of arm. Additionally, she also experienced myoclonic jerks and dizziness. On admission, her vitals were within normal limits. She appeared lethargic and non-cooperative during neurological examination. Direct/ indirect light reflexes were positive and pupils were isochoric. In the upper extremities, myoclonus with 2–3 beats was noted. During the EEG studies, generalised spike-wave activity was noted for a second and she felt asleep after a while. While sleeping, spike-wave activity was vanished. The woman was treated with valproic acid for myoclonic seizures. She was also evaluated by the psychiatry team for determination of substance abuse if any. It was revealed that she had misused cannabis 6 months prior to the current presentation. After one week of discharge, she was evaluated at clinic. No myoclonic jerks were noted and control EEG was also within normal limits. Author comment: "In our case, the patient had never used pregabalin before but had a history of substance abuse. As pointed before, pregabalin misuse is mostly associated with substance use disorders. . .Pregabalin overdose is thought to be safe and complications are rare. In this case, after high dose nasal pregabalin inhalation, the patient had myoclonic seizure." Ozturk HM, et al. Nasal pregabalin overdose and myclonus: a new way of misuse. Psychiatry and Clinical Psychopharmacology 29: 216-219, No. 2, 2019. Available 803431789 from: URL: http://doi.org/10.1080/24750573.2017.1422959 - Turkey
0114-9954/19/1778-0001/$14.95 Adis © 2019 Springer Nature Switzerland AG. All rights reserved
Reactions 9 Nov 2019 No. 1778
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