Preparation and characterization of dissolving hyaluronic acid composite microneedles loaded micelles for delivery of cu
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SHORT COMMUNICATION
Preparation and characterization of dissolving hyaluronic acid composite microneedles loaded micelles for delivery of curcumin Ziting Cheng 1 & Hua Lin 2 & Zhen Wang 1 & Xiaoyu Yang 1 & Mei Zhang 1 & Xuechun Liu 1 & Bingjie Wang 1 & Zhenfeng Wu 3 & Daquan Chen 1
# Controlled Release Society 2020
Abstract In order to improve the bioavailability of curcumin (Cur) and patient compliance, a type of novel hyaluronic acid (HA) composite microneedles containing Cur-loaded micelles was designed in this paper. On the one hand, the microneedles matrix solution was prepared by screening the optimal concentration of HA and the better proportion of HA to sodium carboxymethyl starch (CMSNa). On the other hand, the amphiphilic polymer, named as Quercetin-Dithiodipropionic Acid-Oligomeric Hyaluronic Acid (Que-DA-oHA), was synthesized and characterized using 1H-NMR. Subsequently, the dialysis method was used to prepare Curloaded Que-DA-oHA micelles with an average size of 172.6 ± 11.4 nm and zeta potential of − 33.71 ± 0.45 mV. A micromolding process was used to prepare the micelle-loaded HA composite microneedles. It had been found that when the concentration of HA was 200 mg/mL and the mass ratio of HA to CMS-Na was 2:1, the prepared HA composite microneedles had good mechanical strength. In-skin dissolution kinetics showed that the micelle-loaded HA composite microneedles could dissolve quickly in the skin. In vitro permeation study indicated that the microneedles delivered 74.7% of their drug load over 6 h, which exhibited remarkable drug permeation properties in a short time. Here, we creatively combined micellar technology with microneedle technology to rapidly deliver Cur transdermally for diseases treatment such as melanoma. Keywords Curcumin . Hyaluronic acid . Composite microneedles . Sodium carboxymethyl starch . Micelle-loaded nanoparticle
Introduction Transdermal drug delivery system (TDDS) is a favorable route for drug delivery in which drugs are absorbed into the blood Ziting Cheng and Hua Lin contributed equally to this work. * Zhenfeng Wu [email protected] * Daquan Chen [email protected] 1
School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, People’s Republic of China
2
Medical Center, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong, People’s Republic of China
3
Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, People’s Republic of China
through the skin and then circulate through the blood to the lesion site. TDDS can effectively avoid the first-pass effect, maintain stable blood concentration, improve patient compliance, and reduce side effects [1]. Human skin, a barrier that can protect the body from external substances, is composed of three laye
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