Bacterial Cellulose/Hyaluronic Acid Composites: Preparation and Characterization
The preparation and characterization of bacterial cellulose (BC)/hyaluronic acid (HA) nanocomposites are presented in this paper. BC/HA composites have been prepared by solution immersion method, biosynthesis method, and crosslink method. HA concentration
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Bacterial Cellulose/Hyaluronic Acid Composites: Preparation and Characterization Yuanyuan Jia, Mingming Huo and Shiru Jia
Abstract The preparation and characterization of bacterial cellulose (BC)/hyaluronic acid (HA) nanocomposites are presented in this paper. BC/HA composites have been prepared by solution immersion method, biosynthesis method, and crosslink method. HA concentration (1, 10, and 12.5 g/L) was used as a variable factor. These materials were characterized by Field Emission Scanning Electron Microscopy (FESEM), Fourier Transform Infrared (FTIR) spectroscopy, and X-ray Diffraction (XRD). And tensile strength and young’s modulus were tested for composites from solution immersion and biosynthesis. SEM graphs of the composites show that HA penetrated inside the cellulose network, filling the space of the network, and keeping a close interaction with the nanofibrils. FTIR spectra illustrate the integration of HA in the composites derived by solution immersion and crosslink method. The crystallinity index of all three composites was reduced slightly compared with pristine BC, known from XRD spectra. For composites from solution immersion and biosynthesis, the young’s modulus and tensile strength of BC/HA have been improved compared with the pure BC. This is due to the enhanced hydrogen bonds offered by the interaction between HA and BC. In summary, all the three methods can provide composites of BC and HA. Further, biocompatibility tests will be carried out to evaluate these materials in terms of the potential applications on the biomedical field. Keywords Bacterial cellulose
Composite Crosslink Hyaluronic acid
Y. Jia M. Huo S. Jia Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin 300457, People’s Republic of China Y. Jia (&) M. Huo College of Material Science and Chemical Engineering, Tianjin University of Science and Technology, Tianjin 300457, People’s Republic of China e-mail: [email protected]
T.-C. Zhang et al. (eds.), Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012), Lecture Notes in Electrical Engineering 249, DOI: 10.1007/978-3-642-37916-1_39, Ó Springer-Verlag Berlin Heidelberg 2014
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39.1 Introduction Cellulose is the most abundant biopolymer and has global economic importance, widely existing in plants. Cellulose is a water-insoluble polysaccharide used at an industrial scale for the manufacture of paper and films, or in the powder, natural, hydrolyzed, or derivative form [1]. In the early 1986s a new type of cellulose morphology was developed by Brown et al. [2]., known as bacterial cellulose or BC. Bacterial cellulose (BC) is a nano-scale polyglucose generated from Gluconacetobacter Xylinum, possessing an interesting biocompatibility [3]. What is more, bacterial cellulose has a three-dimensional polymeric network, which is able to absorb and retain large volume of water, as well as possessing large surface area. So BC is widely used in medical fields, such as artificial sk
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