Preparation, characterization, and application of soluble liquid crystalline molecularly imprinted polymer in electroche
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RESEARCH PAPER
Preparation, characterization, and application of soluble liquid crystalline molecularly imprinted polymer in electrochemical sensor Li-Ping Zhang 1 & Ze-Hui Wei 2 & Su-Na He 1 & Yan-Ping Huang 2 & Zhao-Sheng Liu 2 Received: 4 June 2020 / Revised: 27 July 2020 / Accepted: 5 August 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract A novel soluble molecularly imprinted polymer (SMIP) without chemical cross-linker was successfully synthesized. The quinine (QN), which the structure was similar to the template, was chosen as the immobile template to improve the affinity of MIP. 4Methyl phenyl dicyclohexyl ethylene (MPDE) was used as the liquid crystal (LC) monomer to increase the rigid of the composite. The cooperative effect of QN and MPDE was demonstrated by comparing with the conventional MIP, which synthesized without QN and MPDE. The polymerization conditions of SMIP including the ratio of MAA to MPDE, template to functional monomer, and HQN to QN were also optimized. Moreover, the characterizations of the SMIP were investigated by the transmission electron microscopy (TEM), field emission scanning electron microscopy (SEM), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and nitrogen adsorption. In binding behavior, the SMIP presented the maximum adsorption capacity (0.37 ± 0.06 mmol/g) and imprinting factor (3.44 ± 0.25). And above all, the obtained polymer exhibited the solubility in the organic solution. In addition, the proposed SMIP as the electrochemical sensor exhibited a significant conductivity and sensitivity with the detection limit of 0.33 μM for HQN, the recoveries for the sample analysis varied from 97.4 to 100.8%, and the intra-day precision and inter-day precision were within 5.5% and 12.5%, respectively. It turned out that the SMIP had demonstrated more excellent potential than the traditional insoluble MIP in the development of the membrane-based electrochemical sensors. Keywords Soluble molecular imprinted polymer . Immobile template . Liquid crystal monomer . Recognition performance
Introduction Molecular imprinting is an emerging technology that could prepare the polymer with better specific recognition performance for template molecule [1], and the resultant composite Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00216-020-02866-4) contains supplementary material, which is available to authorized users. * Yan-Ping Huang [email protected] * Zhao-Sheng Liu [email protected] 1
School of Basic Medical Sciences, Henan University of Science and Technology, Luoyang 471000, Henan, China
2
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China
was called molecularly imprinted polymer (MIP), which was prepared by polymerization with the initiator in the presence of template molecule, functional monomer, and cross-linking agent. After removing the template molecul
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