Water treatment by molecularly imprinted polymer nanoparticles
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1169-Q04-07
Water treatment by molecularly imprinted polymer nanoparticles T. Schreiber1, A. Weber1,2, K. Niedergall1, J. Riegler1,2, D. Bryniok2, T. Hirth1,2, G. Tovar1,2* 1 University of Stuttgart, Institute for Interfacial Engineering IGVT 2 Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB Nobelstraße 12, 70569 Stuttgart, Germany *[email protected] ABSTRACT Molecular recognition capabilities are evoked at artificial materials by the NANOCYTES®-technology of the Fraunhofer IGB, Stuttgart, Germany. The biomimetic nanoparticles described here possess such molecularly recognizing properties. For this purpose they carry molecularly defined binding sites at their surface. In this particular case molecularly imprinted nanospheres (nanoMIPs) were developed for the specific adsorption of micropollutants from hospital waste water. Active pharmaceutical substances and their metabolites which were not decomposed by waste water plants were chosen as model compounds. One of this model compounds is Pentoxifylline. The nanoMIPs are prepared by a miniemulsion polymerization technique, where the monomer, the template, the cross-linker, and the initiator do react in the droplet cavities of the miniemulsion. The reaction to obtain nanoMIP particles is complex, but nevertheless it runs in a single reaction chamber and in a single step chemical process. For synthesis of the polymer system p(methacrylicacid-co-ethylenglycoldimethacrylate), p(methacrylicacid-co-methylmethacrylate-co-ethylenglycoldimethacrylate) and p(4-vinylpyridin-coethylenglycoldimethacrylate) are used. The technique of miniemulsion polymerization results in particles with a typical size distribution of 50 nm to 500 nm. Additionally, an introduced magnetic core will allow the final separation of the nanoMIPs and more important of the recognized pollutants from (waste) water. We demonstrate that magnetite can be incorporated into the polymer system, and that the template Pentoxifylline does not affect the polymerization process. INTRODUCTION Entirely synthetic receptors which combine the specificity of binding sites with the superior chemical stability of synthetic materials are most desired moieties. Molecularly imprinted nanoparticles come close to such an ideal. Molecular imprinting is a sophisticated way to introduce specific molecular binding sites in otherwise non-functional materials. Imprinted nanoparticles can be prepared by miniemulsion polymerization.1-4 Molecularly imprinted nanospheres (nanoMIPs) can be used as highly specific adsorber of micropollutants, e. g. for Carbamazepin, Oxcarbazepin, Diclofenac or Pentoxifylline.5 Pentoxifylline (figure 1) was selected as a model drug, due to the fact the this molecule contains various functional groups. These functional groups could potentially interact with different monomers prior to polymerization in the fabrication process of the nanoMIPs. Performing experiments with Pentoxifylline will lead to a deeper understanding of the influence of functional groups on the nanoMIP fab
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