Preparation of Alum-borneol-PVP Drug-loaded Fibers by Electrospinning
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doi: 10.1007/s40242-020-0225-9
Article
Preparation of Alum-borneol-PVP Drug-loaded Fibers by Electrospinning HUANG Libing1#, LIU Yueqi1#, SANG Xinyu2, SONG Jinghui1, HU Ping2 and LIU Yong2* 1. College of Mechanical and Electric Engineering, Beijing University of Chemical Technology, Beijing 100029, P. R. China; 2. Beijing Key Laboratory of Advanced Functional Polymer Composites, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, P. R. China Abstract The alum-borneol nanoemulsion(ABN), which combines the mineral medicine alum and the botanical medicine borneol, has been applied for approximately 40 years in the clinical treatment of burns, scalds, radiation dermatitis and shingles, and has a good curative effect. However, the current formula and dosage form of ABN pose problems of low borneol content and ease of precipitation, which greatly affects the efficacy of the drug. In this study, polyvinylpyrrolidone(PVP) was selected as a carrier mixed with different proportions of alum and borneol to produce alum-borneol-PVP fibers(ABPF) by electrospinning. The results showed that the stable system with good drug dispersion was 2:3(alum:borneol). The dissolution content of borneol from the ABPF was about 80% in 4 h, which was much higher than that of the alum-borneol liquid(ABL) and ABN. The ABPF membrane showed a more significant inhibitory effect on Staphylococcus aureus than the ABL and ABN. The composite fiber markedly increased the drug content of borneol, which was 800 times of that in ABN. The fiber had a higher solubility than the nanoemulsion in vitro, which is of great importance for the development of new forms for the clinical application of alum and borneol. Keywords Drug delivery; Dissolution content; Bioavailability; Antibacterial; Fiber membrane
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Introduction
Alum, known as a mineral herbal medicine, is a crystal. Its main ingredient is KAl(SO4)2·12H2O, which has antiinflammatory and astringent effects[1]. Another most common botanical medicine, borneol, has the effects of reducing swelling, inducing analgesia, inhibiting bacteria and fungi, and promoting transdermal absorption of drugs[2―5]. When alum and borneol are used together, they have outstanding performance in the treatment of pediatric aphthous and gynecological diseases[6,7]. In 1975, a suspension consisting mainly of alum and borneol was made and named alum-borneol liquid(ABL)[8]. ABL was found to be effective in treating burns and scalds, shingles, drug-induced phlebitis, and radiation dermatitis[9―12]. However, ABL was a thermodynamically unstable and coarsely dispersed suspension. The main component of this composite herbal medicine, borneol, was easy to crystallize and precipitate because of its extremely low solubility in water, which made it unevenly dispersed and have a low utilization rate. Therefore, based on the formula of ABL, Xiong and Liu et al.[13,14] utilized nanotechnology to make an alum-borneol nanoemulsion(ABN), which was thermodynamically stable and conducive to dru
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