Preparation of Titanium Oxide-Based Nanoparticles Modified with D-(+)-Mannose and Investigation of their Properties As A
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ORIGINAL PAPER
Preparation of Titanium Oxide-Based Nanoparticles Modified with D(+)-Mannose and Investigation of their Properties As A Potential Drug Carrier Jolanta Pulit-Prociak1 • Anita Staron´1 • Olga Długosz1 • Klaudia Kluz1 • Marcin Banach1 Received: 20 April 2020 / Accepted: 8 September 2020 The Author(s) 2020
Abstract Titanium oxide nanoparticles modified with D-(?)-mannose were obtained. In the process of their formation, they were conjugated with an active substance (tadalafil). The physicochemical properties of the obtained products were assessed, and the size and electrokinetic potential were determined using a dynamic light scattering technique. X-ray diffractometry was applied in order to define the crystalline properties, and Fourier-transform infrared spectroscopy was used to confirm the formation of the desired products. It was possible to obtain TiO2 coated with D-(?)-mannose. The average size of nanoparticles was between 230 and 268 nm. The release of the active substance from the product over a time period of three hours was assessed against the reference material, which was not modified by D-(?)-mannose. The results indicate that covering titanium oxide nanoparticles with the modifying substance favours a slower rate of release for the active substance, which is the desired effect from a pharmacological point of view. The releasing of active substance from modified products was even 68% slower than that from the reference product. These modified titanium oxides are promising materials that may have found an application as drug carriers.
& Jolanta Pulit-Prociak [email protected] Anita Staron´ [email protected] Olga Długosz [email protected]
Marcin Banach [email protected] 1
Faculty of Chemical Engineering and Technology, Institute of Chemistry and Inorganic Technology, Cracow University of Technology, Warszawska 24, 31-155 Cracow, Poland
Klaudia Kluz [email protected]
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J. Pulit-Prociak et al.
Graphic Abstract
Keywords Medicine delivery systems Aldohexosis Tadalafil Active substance releasing
Highlights • D-(?)-mannose modification of TiO2 nanostructures leads to produce an effective drug carrier • Coating with D-(?)-mannose does not interference the stability of TiO2 nanoparticles • Modification with D-(?)-mannose results in slower releasing of the active substance
Introduction Over the years, the use of nanomaterials has become increasingly widespread in numerous technological applications [1–3]. Recently, the nanomaterials have been used in medicine, in the diagnosis and treatment of diseases, including carriers of active substances in cancer treatment [4, 5]. Alongside the active substance, the carrier is confirmed to be of crucial value for treatment [6]. Uncontrolled release of the substance, degradation of the active substance, toxic effects of the material on both cancer and healthy cells are only some of the factors that require elimination before the drug can be applied [7]. Bioconjuga
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