Principles of Bone Regeneration
Principles of Bone Regeneration is a timely publication that addresses the modern aspects of bone healing and repair. This exciting new volume details the convergence of the different experimental and clinical approaches designed for the st
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Jona J. Sela
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Itai A. Bab
Editors
Principles of Bone Regeneration
Editors Jona J. Sela Laboratory of Biomineralization Institute of Dental Sciences The Hebrew University Hadassah – Faculty of Dental Medicine Jerusalem, Israel
Itai A. Bab Bone Laboratory Institute of Dental Sciences The Hebrew University of Jerusalem Jerusalem, Israel
ISBN 978-1-4614-2058-3 e-ISBN 978-1-4614-2059-0 DOI 10.1007/978-1-4614-2059-0 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2012933362 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Bone healing is the process whereby deficiencies and discontinuities in bone tissue are repaired by a regeneration process that rescues the biomechanical properties of the skeleton. Inevitably, this process involves an ultimate net gain in the amount of mineralized matrix at the affected sites. This gain may progress slowly, as in the case of the positive shift of bone remodeling balance induced in the osteoporotic skeleton by bone anabolic agents, or, as an outburst of bone formation and remodeling characteristic of the bone tissue reaction to traumatic insults. The importance of bone healing to medicine and biomedical research is illustrated by the number of publications on the different aspects of the subject, which exceeded 2,000 in 2011 alone. Either form of bone healing is affected by a multitude of genetic, environmental, mechanical, cellular, and endocrine variables which eventually lead to changes in gene expression that enhance the guided action of osteoblasts (and chondroblasts) to lay down bone that restores, or even improves, the skeletal load bearing capacity and body motion. Needless to say, osteoclasts are also involved in shaping the healed tissue. Recent breakthroughs in understanding the regulatory aspects of bone formation and resorption, at the basic, translational, and clinical arenas, offer new modalities to induce, enhance, and guide repair processes in bone for the benefit of millions of patients with conditions such as osteoporosis, nonunion fractures, critical size defects, orthodontic tooth movement, periodontal bone loss, intraosseous implants, and deformed bones. An immense number of approaches to treating these c
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