Bone Morphogenetic Proteins: Regeneration of Bone and Beyond
Since the discovery of the bone morphogenetic proteins (BMPs) more than 15 years ago, there has been an unpredicted explosion of both basic scientific discoveries and clinical reports on their use from institutions all over the world. The potent effica c
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Series Editor Prof. Dr. Michael J. Parnham Senior Scientific Advisor PLiVA dd Prilaz baruna Filipovica 25 10000 Zagreb Croatia
Advisory Board G. Z. Feuerstein (Merck Research Laboratories, West Point, PA, USA) M. Pairet (Boehringer Ingelheim Pharma KG, Biberach a. d. Riss, Germany) W. van Eden (Universiteit Utrecht, Utrecht, The Netherlands)
Forthcoming titles: Antirheumatic Therapy: Actions and Outcomes, R.O. Day, D.E. Furst, P.L. van Riel, B. Bresnihan (Editors), 2004 Antibiotics as Anti-inflammatory and Immunomodulatory Agents, B.K. Rubin, J. Tamaoki (Editors), 2004 (Already published titles see last page.)
Bone Morphogenetic Protei ns: Regeneration of Bone and Beyond
Siobodan Vukicevic Kuber T. Sampath Editors
Springer Basel AG
Editors Prof. Dr. Siobodan Vukicevic Laboratory for Mineralized TIssues School of Medicine Salata 11 HR-10000 Zagreb Croatia
Dr. Kuber T. Sampath Genzyme Corporation One Mountain Road Framingham, MA 01701-9322 USA
A CIP catalogue record for this book is available from the Library of Congress, Washington D.C., USA
Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the internet at http://dnb.ddb.de
ISBN 978-3-0348-9598-9
ISBN 978-3-0348-7857-9 (eBook)
DOI 10.1007/978-3-0348-7857-9 The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use.
This work is subject to copyright. AII rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained.
© 2004 Springer Basel AG
Originally published by Birkhauser Verlag, Basel, Switzerland in 2004 Printed on acid-free paper produced from chlorine-free pulp. TCF = Cover design: Markus Etterich, Basel Cover illustration:Newly regenerated embryonic-like structures (in the middle) within a remnant kidney of aged rats in which 5/6 of their original kidney mass has been surgically removed. These animals with chronic renal failure were then systematically treated with BMP-7 for a period of 32 weeks (see p. 229).
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Contents
List of contributors
.
vii
Preface
ix
Kuber T. Sampath Bone morphogenetic proteins and their role in regenerative medicine
1
Olexander Korchynskyi, Rutger L. van Bezooijen, Clemens WG.M. L6wik and Peter ten Dijke Bone morphogenetic protein receptors and their nuclear effectors in bone formation
9
Sn
