Principles of Diabetes Mellitus

Principles of Diabetes Mellitus, Second Edition is an important update to the comprehensive textbook first published in 2002 and reissued in 2004. It is written for physicians of all specialties who, on a daily basis, deal with an illness which has reache

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Leonid Poretsky Editor

Principles of Diabetes Mellitus Second Edition

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Editor Leonid Poretsky Division of Endocrinology and Metabolism Beth Israel Medical Center 317 East 17th Street New York, NY 10003 USA [email protected]

ISBN 978-0-387-09840-1 e-ISBN 978-0-387-09841-8 DOI 10.1007/978-0-387-09841-8 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2009939995 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

Preface to the Second Edition

Seven years have elapsed since the first edition of the Principles of Diabetes Mellitus appeared. It is sobering to realize how much new important information on the subject of this textbook has been developed during this relatively short period of time. Hence, the second edition. Every chapter has been updated in terms of both material it covers as well as the references and the websites where additional useful information can be found. Several new chapters have been added. These chapters cover such topics as the role of brain in glucose metabolism, the role of incretins in the pathogenesis and therapy of diabetes, the relationship between diabetes and cancer and between diabetes and human immunodeficiency virus infection, diabetes among minorities, and hospital management of diabetes. Many authors who contributed to the first edition worked on the second edition as well, but many new writers joined the “crew.” We thank all of the authors of the first edition for their role in preparing this textbook. The goals of this text are outlined in the preface to the first edition, which follows. We hope that our readers will continue to find Principles of Diabetes Mellitus both useful and enjoyable. New York 2009

Leonid Poretsky

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Preface to the First Edition

Diabetes mellitus is a very common disease. Described initially in the Egyptian papyrus Ebers in 1500 BC and now affecting approxima