Principles of Personalized Oncology

This chapter describes the general principles and basics of personalized therapy of cancer. The biggest challenge for optimal treatment outcomes in cancer patients is the complex nature of the disease due to cellular heterogeneity and dysfunction of numer

  • PDF / 9,853,644 Bytes
  • 770 Pages / 504.63 x 737.01 pts Page_size
  • 25 Downloads / 168 Views

DOWNLOAD

REPORT


3

Textbook of Personalized Medicine

Kewal K. Jain

Textbook of Personalized Medicine Third Edition

Kewal K. Jain Jain PharmaBiotech Basel, Switzerland

ISBN 978-3-030-62079-0    ISBN 978-3-030-62080-6 (eBook) https://doi.org/10.1007/978-3-030-62080-6 © Springer Nature Switzerland AG 2021 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Preface to the 3rd Edition

Considerable advances have taken place in personalized medicine since the 2nd edition of this textbook in 2015, requiring rewriting. Approximately 50% of the old material has been replaced, although historical and classical items have been retained. The text has been expanded and is supplemented with 69 tables and 41 illustrations. References are appended at the end of each chapter and the total number has increased to approximately 1000 despite deletion of older references. Most new developments have occurred in personalized oncology and the original chapter has been split into three, with personalized immuno-oncology as a separate chapter. As in previous editions, the uniform style of a single-author book has been maintained. The audience of physicians, pharmacists, research scientists, healthcare providers, and biotechnology and pharmaceutical companies is kept in mind. Lay readers and patients, who are important participants in personalized medicine, can understand this book if they have a basic science education. The title “Personalized Medicine” has been retained from the first monograph on this topic by the author in 1998. Recently, there is an effort to replace it by “Precision Medicine,” a term that has been used in this book as well as in previous editions as one of a dozen terms used for the description of personalize