Principles of Surgical Oncology

Surgery remains the most effective and the only curative treatment for the majority of cancer patients with solid tumors. The earliest accounts of surgical treatment of tumors are found in the Papyrus dating back to 1600 BC [1 ]. In the modern era, McDowe

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Springer-Verlag Berlin Heidelberg GmbH

Everett E.Vokes Harvey M. Golomb (Editors)

Oncologic Therapies Second, Completely Revised and Updated Edition with 43 Figures and 208 Tables

123

Professor Everett E. Vokes, M.D. Professor Harvey M. Golomb, M.D. University of Chicago, Medical Center 5841 S. Maryland Avenue, MC 2115 Chicago, IL 60637-1470, USA

ISBN 978-3-642-62818-4

Library of Congress Cataloging-in-Publication Data Oncologic therapies / Everett E. Vokes, Harvey M. Golomb, editors.--2nd completely rev. and updated ed. p. ; cm. Includes bibliographical references and index. ISBN 978-3-642-62818-4 ISBN 978-3-642-62818-4

ISBN 978-3-642-55780-4 (eBook)

DOI 10.1007/978-3-642-55780-4 1. Cancer--Treatment--Handbooks, manuals, etc. I. Vokes, E. E. (Everett E.), 1954- II. Golomb, Harvey M. (Harvey Morris), 1943- [DNLM: 1. Neoplasms-therapy. QZ 266 O583 2003] RC270.8 .O53 2003 616.99’406--dc21 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from SpringerVerlag. Violations are liable for prosecution under the German Copyright Law. http://www.springer.de © Springer-Verlag Berlin Heidelberg 1999, 2003 Originally published by Springer-Verlag Berlin Heidelberg New York in 2003 Softcover reprint of the hardcover 2nd edition 2003 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about the application of operative techniques and medications contained in this book. In every individual case the user must check such information by consulting the relevant literature. Production: PROEDIT GmbH, Heidelberg Cover design: d’blik, Berlin Typesetting: Fotosatz-Service Köhler GmbH, Würzburg Printed on acid-free paper

SPIN: 10843086

21/3150/hs

543210

Preface

Our goal for this second edition of Oncologic Therapies is to again provide a brief introduction to the principles and practice of oncology and to oncologic therapies. The book provides a description of the major treatment modalities including surgery, radiation therapy, and systemic therapies including classic chemotherapy and biological therapies as well as a brief overview of supportive care and quality of life assessments. This is followed by a discussion of site-specific cancers covering the hematologic malignancies and solid tumors. Each chapter is designed to provide a brief discussion of background information including epide