Progesterone receptor does not improve the performance and test effectiveness of the conventional 3-marker panel, consis
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Progesterone receptor does not improve the performance and test effectiveness of the conventional 3-marker panel, consisting of estrogen receptor, vimentin and carcinoembryonic antigen in distinguishing between primary endocervical and endometrial adenocarcinomas in a tissue microarray extension study Chiung-Ling Liao†1,2, Ming-Yung Lee†3, Yeu-Sheng Tyan†4,5, Lai-Fong Kok6, Tina S Wu7, Chiew-Loon Koo8, Po-Hui Wang2, Kuan-Chong Chao9 and ChihPing Han*1,2,3 Address: 1Department of Obstetrics and Gynecology, Chung-Shan Medical University Hospital, Taichung, Taiwan, 2Institute of Medicine, ChungShan Medical University, Taichung, Taiwan, 3Clinical Trial Center, Chung-Shan Medical University Hospital, Taichung, Taiwan, 4Department of Medical Imaging, Chung-Shan Medical University Hospital, Taichung, Taiwan, 5Department of Medical Imaging and Radiological Science, ChungShan Medical University, Taichung, Taiwan, 6Department of Pathology, China Medical University Hospital, Taichung, Taiwan, 7David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA, 8Department of Pathology, Chung Shan Medical University Hospital, Taichung, Taiwan and 9Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, and Division of Obstetrics and Gynecology, Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan Email: Chiung-Ling Liao - [email protected]; Ming-Yung Lee - [email protected]; Yeu-Sheng Tyan - [email protected]; LaiFong Kok - [email protected]; Tina S Wu - [email protected]; Chiew-Loon Koo - [email protected]; PoHui Wang - [email protected]; Kuan-Chong Chao - [email protected]; Chih-Ping Han* - [email protected] * Corresponding author †Equal contributors
Published: 28 May 2009 Journal of Translational Medicine 2009, 7:37
doi:10.1186/1479-5876-7-37
Received: 29 April 2009 Accepted: 28 May 2009
This article is available from: http://www.translational-medicine.com/content/7/1/37 © 2009 Liao et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Objective: Endocervical adenocarcinomas (ECA) and endometrial adenocarcinomas (EMA) are uterine malignancies that have differing biological behaviors. The choice of an appropriate therapeutic plan rests on the tumor's site of origin. In this study, we propose to evaluate whether PR adds value to the performance and test effectiveness of the conventional 3-marker (ER/Vim/ CEA) panel in distinguishing between primary ECA and EMA. Methods: A tissue microarray was constructed using paraffin-embedded, formalin-fixed tissues from 38 hysterectomy specimens, including 14 ECA and 24 EMA. Tissue microarray (TMA) sections were immunostained with 4 antibodies, using the avidin-biotin complex (ABC)
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