Prognostic Role of Time to Surgery in Hepatocellular Carcinoma at Barcelona Clinic Liver Cancer Stage 0-A
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ORIGINAL ARTICLE – HEPATOBILIARY TUMORS
Prognostic Role of Time to Surgery in Hepatocellular Carcinoma at Barcelona Clinic Liver Cancer Stage 0-A Mengchao Wei, MD1, Shuling Chen, MD2, Jiali Li, MD3, Bin Li, MSc4, Jingxian Shen, MD5, Zhenwei Peng, MD4,6, Qian Zhou, MSc4, Ying Zou, MM7, Xiaofang He, MD6, Shaoqiang Li, MD1, Dongming Li, MD1, Baogang Peng, MD1, Jiaming Lai, MD8, Sui Peng, MD4,9, Beijiao Qin, MB10, and Ming Kuang, MD1,2,11,12 1
Department of Liver Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; 2Division of Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; 3Department of General Surgery, Dongguan People’s Hospital, Dongguan, China; 4Clinical Trials Unit, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; 5Department of Medical Imaging, Cancer Center of Sun Yat-sen University, Guangzhou, China; 6Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; 7Department of Medical Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; 8Department of Pancreatobiliary Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; 9Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; 10Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China; 11Cancer Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; 12Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
ABSTRACT Background. Postsurgical recurrence is common in earlystage hepatocellular carcinoma (HCC). Prolonged time to surgery (TTS) may lead to tumor progression. However, the impact of TTS on HCC prognosis is controversial in Western studies and unknown in China. We aim to investigate the impact of TTS on the prognosis of Chinese HCC patients at Barcelona Clinic Liver Cancer (BCLC) stage 0-A who underwent surgery. Patients and Methods. We retrospectively enrolled 967 BCLC 0-A HCC patients who underwent surgery at three
Electronic supplementary material The online version of this article (https://doi.org/10.1245/s10434-020-08499-2) contains supplementary material, which is available to authorized users. Mengchao Wei, Shuling Chen, and Jiali Li have contributed equally to this paper. Ó Society of Surgical Oncology 2020 First Received: 25 November 2019 M. Kuang, MD e-mail: [email protected]
tertiary centers in China. Primary outcomes were recurrence-free survival (RFS) and overall survival (OS). Restricted cubic spline (RCS) was used to select the cutoff value of TTS. Propensity score matching (PSM) was performed to reduce confounding bias, and a time-dependent Cox model was utilized to investigate factors influencing TTS. Results. The median TTS of BCLC 0-A HCC patients was 13 days (interquartile range: 10–21 days). For patients with TTS B 70 days, the cutoff value of TTS was
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