Prognostic significance of autophagy-related genes within esophageal carcinoma
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RESEARCH ARTICLE
Open Access
Prognostic significance of autophagyrelated genes within esophageal carcinoma Chongxiang Chen1,2†, Siliang Chen3†, Huijiao Cao4†, Jiaojiao Wang5, Tianmeng Wen6, Xiaochun Hu3* and Huan Li1*
Abstract Background: Several works suggest the importance of autophagy during esophageal carcinoma development. The aim of the study is to construct a scoring system according to the expression profiles of major autophagy-related genes (ARGs) among esophageal carcinoma cases. Methods: The Cancer Genome Atlas was employed to obtain the esophageal carcinoma data. Thereafter, the online database Oncolnc (http://www.oncolnc.org/) was employed to verify the accuracy of our results. According to our results, the included ARGs were related to overall survival (OS). Results: We detected the expression patterns of ARG within esophageal carcinoma and normal esophageal tissues. In addition, we identified the autophagy related gene set, including 14 genes displaying remarkable significance in predicting the esophageal carcinoma prognosis. The cox regression results showed that, 7 ARGs (including TBK1, ATG5, HSP90AB1, VAMP7, DNAJB1, GABARAPL2, and MAP2K7) were screened to calculate the ARGs scores. Typically, patients with higher ARGs scores were associated with poorer OS. Moreover, the receiver operating characteristic (ROC) curve analysis suggested that, ARGs accurately distinguished the healthy people from esophageal carcinoma patients, with the area under curve (AUC) value of > 0.6. Conclusion: A scoring system is constructed in this study based on the main ARGs, which accurately predicts the outcomes for esophageal carcinoma. Keywords: Esophageal carcinoma, Autophagy, Prognostic
Background Nowadays, studies around the world show that, esophageal carcinoma ranks the 7th and 6th places in terms of its morbidity tumor-related mortality cause [1]. However, the area distribution is imbalanced between cases and deaths, * Correspondence: [email protected]; [email protected] † Chongxiang Chen, Siliang Chen and Huijiao Cao contributed equally to this work. 3 Department of hematology, State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China 1 Department of Intensive Care Unit, State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dongfeng Dong Road, Guangzhou 510060, People’s Republic of China Full list of author information is available at the end of the article
and some areas are regarded as the “esophageal carcinoma belt” [2, 3]. Several factors, such as smoking, obesity, low vegetable consumption, have been proven to adversely predict esophageal carcinoma [4, 5]. Nowadays, an increasing obesity trend in western countries results in the further increased esophageal carcinoma morbidity [1], as proven in one meta-analysis [6]. So far, several prognostic studies have used various indicators (including PET-CT [7], HER2 [8],
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