Prognostic significance of serum inflammatory markers in esophageal cancer
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ORIGINAL ARTICLE
Prognostic significance of serum inflammatory markers in esophageal cancer Arfon G. M. T. Powell1 · Catherine Eley2 · Carven Chin2 · Alexandra H Coxon2 · Adam Christian3 · Wyn G. Lewis2 · South East Wales Oesophagogastric Cancer Collaborative Received: 18 February 2020 / Accepted: 24 August 2020 © The Author(s) 2020
Abstract Background The aim of this study was to assess the relative prognostic value of biomarkers to measure the systemic inflammatory response (SIR) and potentially improve prognostic modeling in patients undergoing potentially curative surgery for esophageal adenocarcinoma (EC). Methods Consecutive 330 patients undergoing surgery for EC between 2004 and 2018 within a regional UK cancer network were identified. Serum measurements of haemoglobin, C-reactive protein, albumin, modified Glasgow Prognostic Score (mGPS), and differential neutrophil to lymphocyte ratio (NLR) were obtained before surgery, and correlated with histopathological factors and outcomes. Primary outcome measures were disease-free (DFS) and overall survival (OS). Results Of 330 OC patients, 294 underwent potentially curative esophagectomy. Univariable DFS analysis revealed pT, pN, pTNM stage (all p
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