Progressively Enlarging Goiter: Case Reports of Primary Thyroid Lymphoma and Literature Review
- PDF / 1,210,841 Bytes
- 5 Pages / 595.276 x 841.89 pts (A4) Page_size
- 82 Downloads / 166 Views
40(3):1-5,2020
1
Progressively Enlarging Goiter: Case Reports of Primary Thyroid Lymphoma and Literature Review Xia-ming LIU1, De-lin MA2, Gang YUAN2, Jun-hui XIE2# 1 Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 2 Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Huazhong University of Science and Technology 2020
Summary: Primary thyroid lymphoma (PTL) is an exceptionally rare and highly aggressive potentially curable malignant disease. We report three typical cases of PTL referred to our hospital. All three cases had long history of Hashimoto’s thyroiditis, and presented with progressively enlarging neck mass. The first two cases were confirmed by surgical biopsy to be diffuse large B cell lymphoma, and received radiotherapy combined with chemotherapy, or received only chemotherapy. The third case was confirmed by core needle biopsy to be mucosa-associated lymphoid tissue lymphoma, and received radiotherapy. In summary, confirmation of PTL diagnosis is essential for further clinical decisions. Core biopsy should be one of the most important methods to make the diagnosis of PTL, while the use of fine needle aspiration cytology alone is still limited in diagnosing PTL. Key words: primary thyroid lymphoma; B-cell lymphoma; Hashimoto’s thyroiditis; fine needle aspiration cytology; core needle biopsy
Primary thyroid lymphoma (PTL) is a rare disease. The majority of thyroid lymphomas are nonHodgkin’s lymphomas of B-cell origin that arise in the setting of thyroiditis. Hodgkin’s lymphoma presenting in the thyroid can mimic primary thyroid carcinoma or thyroiditis, creating diagnostic dilemmas. Here, we report three typical cases of PTL referred to our hospital. All three cases had history of Hashimoto’s thyroiditis, and presented with rapidly growing neck mass. Based on the three cases of PTL, we reviewed the literature and discussed the diagnosis, treatment and prognosis of PTL. 1 CASE REPORT 1.1 Case 1 A 69-year-old woman presented to our hospital in July 2011, complaining of rapid neck swelling for 2 months. She was diagnosed as having Hashimoto’s thyroiditis accompanied with hypothyroidism one year ago, and was treated with thyroxin tablets, but she did not take pills regularly. She also had a history of hypertension and type 2 diabetes, while her family history was unremarkable. Physical examination Xia-ming LIU, E-mail: [email protected] # Corresponding author, E-mail: [email protected]
revealed thyroid enlargement (Class Ⅱ), with several hard and fixed lymph nodes (one about 3 cm×2 cm in size) in the right side of the neck. Laboratory tests showed hypothyroidism and increased thyroid peroxidase antibody (TPO-Ab). Ultrasound suggested Hashimoto’s thyroiditis. Computed tomography (CT) scans of the neck revealed diffuse bilateral thyroid enlargement with uneven density, and increased size and number of cervical lymph nodes, which sugge
Data Loading...
