Protective Effect of Schisandra chinensis Extract Against Ethanol-Induced Gastric Ulcers in Mice by Promoting Anti-infla
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ORIGINAL ARTICLE
Protective Effect of Schisandra chinensis Extract Against Ethanol-Induced Gastric Ulcers in Mice by Promoting Anti-inflammatory and Mucosal Defense Mechanisms Wen-zhang Si 1,2 & Xin-xin Hu 2,3 & Chen Shen 2 & Ming-xiao Luo 2 Guiying Xing 2 & Hua-fang Zhang 5 & Jian Zhang 5 & Zheng Liu 2,5
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Yan-han Xuan 2
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Hai-jing Fu 4
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Received: 18 February 2020 / Accepted: 1 September 2020 # Sociedade Brasileira de Farmacognosia 2020
Abstract Schisandra chinensis (Turcz.) Baill., Schisandraceae, is a common Chinese traditional medicine for the treatment of nervous system disorders and cardiovascular diseases. However, little is known about its efficacy in treating gastrointestinal diseases. In the present study, the protective effect of the ethanol extract of S. chinensis against ethanol-induced acute gastric lesions was investigated in mice. Furthermore, we developed a method based on high-performance liquid chromatography for the quantification of bioactive lignans with a dibenzocyclooctadiene skeleton. The ethanol extract of S. chinensis significantly decreased the ulcer index, sheltered mucosa from lesions, increased levels of superoxide dismutase, decreased malondialdehyde levels, and downregulated plasma levels of tumor necrosis factor-α and interleukin-1β. Our findings demonstrated the gastroprotective properties of the ethanol extract of S. chinensis. Keywords Acute alcohol intake . Cytokines . Gastric mucosa damage . Oxidative stress . Pathological change
Introduction Gastric ulcers are a common type of gastrointestinal disease and exhibit a high prevalence rate. Studies have shown that
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s43450-020-00096-4) contains supplementary material, which is available to authorized users. * Zheng Liu [email protected] 1
Department of General Surgery, Affiliated Hospital of Shaoxing University (Shaoxing Municipal Hospital), Shaoxing 312000, Zhejiang Province, People’s Republic of China
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Department of Forensic Toxicology, Shaoxing University Forensic Center, No. 900 Chengnan Road, Shaoxing 312000, Zhejiang Province, People’s Republic of China
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Cixi Maternity and Child Health Care Hospital, Ningbo 315000, Zhejiang Province, People’s Republic of China
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Chemical College of Shaoxing University, Shaoxing 312000, Zhejiang Province, People’s Republic of China
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Department of Pharmacology, Medical College of Shaoxing University, Shaoxing 312000, Zhejiang Province, People’s Republic of China
the etiology of ulcers is associated with cigarette smoking, stress, infections, nutritional deficiencies, frequent ingestion of non-steroidal anti-inflammatory drugs, and alcohol consumption (Arab et al. 2015; Sidahmed et al. 2019). Among these factors, excessive alcohol consumption has attracted the most attention, as it has been demonstrated to considerably increase the incidence of gastric ulcers (Yamada et al. 2005). However, the pathogenic mechanisms underlying ethanolinduced gastric ulcers have not been full
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