Protein-Protein Interactions as New Drug Targets
Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interac
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Editor-in-Chief F. Hofmann, München
Editorial Board J. Beavo, Seattle, WA D. Ganten, Berlin M. Michel, Amsterdam C. Page, London W. Rosenthal, Berlin
Enno Klussmann • John Scott Editors
Protein–Protein Interactions as New Drug Targets Contributors E.M. Aandahl, A. Bauman, M. Berrera, J. Bode, M.D. Brown, G. Cesareni, N.L. Chudasama, W.M. Cleghorn, S. Costa, S.W. Deacon, K.L. Dodge-Kafka, G. Dodoni, C. Freund, A. Gluch, E.V. Gurevich, V.V. Gurevich, V. Haucke, M.D. Houslay, C. Hundsrucker, E. Huston, P.A. Insel, M.S. Kapiloff, S. Keller, E. Klussmann, D. Krappmann, M. Krause, H.-J. Kreienkamp, R. Kühne, F.-Q. Li, X. Li, S.O. Marx, A.C. McCahill, S. Monterisi, F. Murray, M. Ohmitsu, H.H. Patel, V. Pertegato, J.R. Peterson, G. Pula, C. Rodemer, W. Rosenthal, D.B. Sacks, H.-G. Schmalz, S.F. Steinberg, J. Sticht, H.M. Strauss, K.-I. Takemaru, K. Taskén, K.M. Torgersen, M. Vidakovic, J.W. Walker, E. Wegener, M. Zaccolo, I. Zamparo
John Scott Ph.D. The Vollum Institute Oregon Health & Science University Medical Research Bldg, Rm 322D 3181 SW Sam Jackson Park Road Portland, OR 97239-3098 USA [email protected]
Dr. Enno Klussmann Leibniz-Institut für Molekulare Pharmakologie Robert-Rössle-Str. 10 13125 Berlin Germany [email protected]
ISBN 978-3-540-72842-9
e-ISBN: 978-3-540-72843-6
DOI: 10.1007/978-3-540-72843-6 Handbook of Experimental Pharmacology ISSN 0171-2004 Library of Congress Control Number: 2008920053 © 2008 Springer-Verlag Berlin Heidelberg This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover design: WMXDesign GmbH, Heidelberg Printed on acid-free paper 9 8 7 6 5 4 3 2 1 springer.com
Preface
Biological processes are controlled by protein–protein interactions. The specificity of a protein–protein interaction permits highly selective pharmacological interference with a defined cellular process. Due to the vast diversity of protein–protein interactions they represent a large class of potential drug targets that offer great opportunities for therapeutic intervention. However, targe
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