Reviews on New Drug Targets in Age-Related Disorders

Aging is an inevitable part of life and is becoming a worldwide social, economic and health problem. This is mainly due to the fact that the increasing proportion of individuals in the advanced age category have a higher probability of developing age-rela

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Paul C. Guest  Editor

Reviews on New Drug Targets in Age-Related Disorders

Advances in Experimental Medicine and Biology Proteomics, Metabolomics, Interactomics and Systems Biology Sub-Series Editor Daniel Martins-de-Souza University of Campinas (UNICAMP) Institute of Biology Laboratory of Neuroproteomics Campinas, Brazil

Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields. Advances in Experimental Medicine and Biology has been publishing exceptional works in the field for over 40 years, and is indexed in SCOPUS, Medline (PubMed), Journal Citation Reports/Science Edition, Science Citation Index Expanded (SciSearch, Web of Science), EMBASE, BIOSIS, Reaxys, EMBiology, the Chemical Abstracts Service (CAS), and Pathway Studio. 2018 Impact Factor: 2.126. Content of this series is reviewed. This series of volumes focuses on concepts, techniques and recent advances in the field of proteomics, interactomics, metabolomics and systems biology. Recent advances in various ‘omics’ technologies enable quantitative monitoring of myriad various biological molecules in a high-throughput manner, and allow determination of their variation between different biological states on a genomic scale. Now that the sequencing of various genomes, from prokaryotes to humans, has provided the list and linear sequence of proteins and RNA that build living organisms, defining the complete set of interactions that sustain life constitutes one of the key challenges of the postgenomic era. This series is intended to cover experimental approaches for defining protein-protein, protein-RNA, protein-DNA and protein-lipid interactions; as well as theoretical approaches dealing with data analysis, integration and modeling and ethical issues. More information about this series at http://www.springer.com/series/15040

Paul C. Guest Editor

Reviews on New Drug Targets in Age-Related Disorders

Editor Paul C. Guest Laboratory of Neuroproteomics Department of Biochemistry and Tissue Biology Institute of Biology University of Campinas (UNICAMP) Campinas, Brazil

ISSN 0065-2598     ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-030-42666-8    ISBN 978-3-030-42667-5 (eBook) https://doi.org/10.1007/978-3-030-42667-5 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage a