Protein-Sorption and the Hemostatic Properties of Composite Materials Based on Polyurethane Foam Filled with Silicon and
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PROTEIN-SORPTION AND THE HEMOSTATIC PROPERTIES OF COMPOSITE MATERIALS BASED ON POLYURETHANE FOAM FILLED WITH SILICON AND ALUMINUM OXIDES A. A. Kravchenko,1 I. I. Gerashchenko,1 L. Ya. Shtanova,2,3 T. V. Krupska,1 N. V. Guzenko,1 O. V. Kravchenko,4 I. V. Komarov,2 P. I. Yanchuk,2 S. P. Veselskiy,2 O. V. Tsymbalyuk,2 T. V. Vovkun,3 and V. M. Baban2
UDC 544.72:612.11
An effective hemostatic composite material was obtained due to the combination of water-absorption, protein-sorption, and hemostatic properties of highly dispersed oxides of SiO2 and Al2O3 with the cellular structure of polyurethane foam. It was found that a sample with a silica content of 5 wt.% has the highest parameters of osmotic activity and water absorption. The protein-adsorption activity of the fillers in the composite is slightly reduced, but remains at a level sufficient for the manifestation of biological activity. The hemostatic effect of the composite materials was studied in a model of parenchymal bleeding in rats. Keywords: polyurethane foam, silicon dioxide, aluminum oxide, hemostatic properties, water absorption, protein adsorption, parenchymal bleeding.
Hemorrhagic shock caused by trauma remains the leading cause of death during military operations and the second most common in civilian trauma clinics [1]. Hemostatic agents play a key role in combating hemorrhagic shock and preventing fatalities. There are different hemostatic agents in the form of bandages, napkins, plasters, sponges, etc., which in addition to the inert carrier contain hemostatic substances of synthetic or natural origin, including chitosan, oxidized cellulose, alginate, collagen, gelatin, cyanoacrylic acid-based tissue adhesive, porous zeolite, fibrinogen, and other substances [2, 3]. The trigger mechanism of hemostasis can be implemented in several ways depending on the charge of the active component surface. In particular, positively charged chitosan and its derivatives easily form clots in combination with negatively charged erythrocytes, leukocytes, and platelets, which promotes the secretion of glycosaminoglycans, such as hyaluronic acid, which accelerates wound healing [4]. The surgical hemostatic gauze, made of oxidized cellulose, causes a hemostatic reaction due to the interaction of carboxylic acid groups with erythrocyte hemoglobin and Fe3+ ions, forming a sticky flexible block that closes capillaries and bleeds, thus providing a matrix for platelet adhesion, aggregation, and activation of blood clotting mechanism [5]. The unique feature of synthetic non-porous silicon dioxide draws attention, which is its high adsorption capacity against various proteins [6]. The hemostatic effect of silica is caused by the adsorption with subsequent activation of blood plasma
________ O. O. Chuiko Institute of Surface Chemistry, NAS of Ukraine, Kyiv, Ukraine. E-mail:[email protected]. 2 Institute of High Technologies, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine. 3 Taras Shevchenko National University of Kyiv, Kyiv, Ukraine. 4 O. O. Bogomolets
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