Public involvement in pharmacogenomics research: a national survey on public attitudes towards pharmacogenomics research
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Public involvement in pharmacogenomics research: a national survey on public attitudes towards pharmacogenomics research and the willingness to donate DNA samples to a DNA bank in Japan Eriko Kobayashi Æ Nobunori Satoh
Received: 13 February 2009 / Accepted: 30 June 2009 / Published online: 23 July 2009 Ó Springer Science+Business Media B.V. 2009
Abstract To assess the attitudes of the Japanese general public towards pharmacogenomics research and a DNA bank for identifying genomic markers associated with ADRs and their willingness to donate DNA samples, we conducted a national survey for 1,103 Japanese adults from the general public, not a patient population. The response rate was 36.8%. The majority of the respondents showed a positive attitude towards pharmacogenomics research (81.0%) and a DNA bank (70.4%). Considering fictitious clinical situations such as taking medications and experiencing ADRs, the willingness to donate DNA samples when experiencing ADRs (61.7%) was higher than when taking medications (45.3%). Older generations were significantly associated with a decreased willingness to donate (OR = 0.45, CI 0.28–0.72 in 50s. OR = 0.49, CI: 0.31–0.77 in 60s). Positive attitudes towards pharmacogenomics research, a DNA bank, blood/bone marrow/organ donation were significantly associated with an increased willingness. However,
the respondents had the following concerns regarding a DNA bank: the confidentiality of their personal information, the manner by which research results were utilized and simply the use of their own DNA for research. In order to attain public understanding to overcome these concerns, a process of public awareness should be put into place to emphasize the beneficial aspects of identifying genomic markers associated with ADRs and to address these concerns raised in our study. Further study is needed to assess the willingness of actual patients taking medications in real situations, since the respondents in our study were from the general public, not a patient population, and their willingness was assessed on the condition of assuming that they were patients taking medications.
E. Kobayashi (&) Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba 260-8675, Japan e-mail: [email protected]
Introduction
N. Satoh Department of Clinical Education and Research, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
Keywords Public attitudes A DNA bank Pharmacogenomics research DNA donation Japan Genomic markers for ADR
Though maximizing efficacy and minimizing adverse reactions of drugs is critical for the appropriate use of drugs, severe adverse drug reactions (ADRs)1 are 1
An adverse drug reaction is noxious, unintended, and occurs at doses normally used in humans (World Health Organization 1971).
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ranked as one of the leading causes of death and illness in hospitalized patients (Lazarou et al. 1998). While various factors are associated with AD
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