Pulmonary Emphysema Impairs Male Reproductive Physiology Due To Testosterone and Oxidative Stress Imbalance in Mesocrice
- PDF / 4,226,378 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 14 Downloads / 206 Views
ORIGINAL ARTICLE
Pulmonary Emphysema Impairs Male Reproductive Physiology Due To Testosterone and Oxidative Stress Imbalance in Mesocricetus auratus Henrique Rodrigues Vieira 1 & Gessica Dutra Gonçalves 1,2 & Nichelle Antunes Vieira 2 & Rafaela Pires Erthal 1,2 & Carolina Ferreira Sampaio 1 & Ingrid Caroline Pinto 2 & Thamara Nishida Xavier Silva 2 & Gláucia Eloisa Munhoz de Lion Siervo 1,2 & Rubens Cecchini 2 & Flávia Alessandra Guarnier 2 & Glaura Scantamburlo Alves Fernandes 1 Received: 20 January 2020 / Accepted: 25 May 2020 # Society for Reproductive Investigation 2020
Abstract This study evaluated whether pulmonary emphysema affects sperm quality, male reproductive organs, and testosterone levels in adult male hamsters. Mesocricetus auratus males (130–150 g) were subdivided into a control group (C group) and an emphysema group (E group). The C group received an intratracheal instillation of saline solution (0.3 mL/100 g of body weight), and the E group received papain (40 mg/100 g of body weight). After 60 days, the biometric, pulmonary, and reproductive parameters of each group were evaluated. The E group developed pulmonary emphysema, which decreased body weight and sperm quality compared to the C group. In oxidative stress-related assays, lipid peroxidation was increased in the testis and epididymis (caput and cauda) in the E group compared with the C group. However, only the caput epididymis showed a reduction in glutathione levels. Pulmonary emphysema also affected the testicle by inducing an increase in abnormal seminiferous tubules, accompanied by a decrease in seminiferous epithelium height. Spermatogenesis kinetics were also modified by pulmonary emphysema. The number of Leydig and Sertoli cells decreased in the E group, accompanied by an increase in the nuclear volume of Leydig cells. Testosterone concentration was increased in the E group. Similarly, pulmonary emphysema altered epididymal components in all regions. In conclusion, pulmonary emphysema affected the reproductive system in this experimental model, as shown by testicular and epididymal morphophysiology changes, hormonal alteration, and oxidative stress imbalance, inducing the loss of correct function in the male reproductive system. Keywords Testis . Epididymis . Sperm quality . Chronic obstructive pulmonary disease
Introduction Male infertility has become a growing problem in recent decades and affects 15% of all couples worldwide. Men represent 40% of infertility cases [1]. The main infertility diagnosis is a decrease in sperm quality. However, chronic diseases * Glaura Scantamburlo Alves Fernandes [email protected] 1
Department of General Biology, State University of Londrina, Londrina, PR, Brazil
2
Department of General Pathology, State University of Londrina, Londrina, PR, Brazil
increase infertility incidence, such as hormonal disbalance [2, 3], obesity [4], diabetes [5], and hypertension [6]. Unfortunately, the connection between chronic disease and reproduction is unknown. Chronic obstructive pulmonary disease (COPD) was repor
Data Loading...
