10.32 Comparison of Local Carotid and Aortic Stiffness Parameters in Mild Essential Hypertensive Patients
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High Blood Press Cardiovasc Prev 2007; 14 (3): 145-196 1120-9879/07/0003-0145/$44.95/0 © 2007 Adis Data Information BV. All rights reserved.
Vessels and Endothelium 10.32 Comparison of Local Carotid and Aortic Stiffness Parameters in Mild Essential Hypertensive Patients C. Giannarelli,1 E. Bianchini, K. Raimo,1 F. Faita, V. Gemignani, M. Demi, L. Ghiadoni,1 S. Taddei,1 A. Salvetti1 ` di Pisa, Pi Pisa; (2) Istituto di Fisiologia Clinica, CNR, Pisa, It Italy (1) Universita Introduction: Local arterial elasticity can be evaluated by measuring both and the diameter changes during the heart cycle from ultrasound scans and local pulse pressure (PP). The aim of this study is to compare measurements of local arterial stiffness with an automatic edge detection system with the carotid-femoral pulse wave velocity (PWV), the “gold standard” for arterial stiffness assessment. Methods: In 15 patients (males 12, age 40±7 years) with mild essential hypertension, without atherosclerotic lesions, and 15 age and gender matched healthy control subjects, we measured carotid pulse pressure (PP) and carotid to femoral PWV by applanation tonometry (SphygmoCor®). Artery diameter changes were measured by a contour tracking algorithm applied to B-mode longitudinal scans of the common carotid artery. The algorithm is implemented on a stand-alone video processing system which acquires and analyses video signal showing results in real-time. Distension (D) was calculated as the difference between systolic and diastolic artery diameter. Compliance (C=D/PP) and distensibility (Dist=C/diastolic diameter) were also calculated. Results: Hypertensive patients showed significantly (p0.51 mm) than controls (6.69±0.40 mm). Local stiffness parameters were significantly increased (D =0.062 mm; C = 0.00842 ± 0.00186 mm/mmHg; Dist = 0.00113±0.00043 mmHg-1) as compared to controls (D = 0.783±0.0745 mm; C = 0.0138 ± 0.00223 mm/mmHg; Dist = 0.00207± 0.00052 mmHg-1). Conclusion: Parameters of common carotid stiffness discriminate mild hypertensive patients from healthy controls. Moreover, these parameters are inversely related with aortic PWV. Therefore, automatic determination of carotid stiffness from ultrasound and aortic PWV provide similar and/or complementary information on large artery stiffness.
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