1034 Comparison of the presence of ischemic-type and non-ischemic-type delayed contrast enhancement and the presence of
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Meeting abstract
1034 Comparison of the presence of ischemic-type and non-ischemic-type delayed contrast enhancement and the presence of regional wall motion abnormalities detected by cardiac MRI in patients after heart transplantation Constanze Merten*, Sonja Refle, Thomas J Dengler, Evangelos Giannitsis, Hugo A Katus and Henning Steen Address: University Hospital Heidelberg, Heidelberg, Germany * Corresponding author
from 11th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 1–3 February 2008 Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A159
doi:10.1186/1532-429X-10-S1-A159
Abstracts of the 11th Annual SCMR Scientific Sessions - 2008
Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdfThis abstract is available from: http://jcmr-online.com/content/10/S1/A159 © 2008 Merten et al; licensee BioMed Central Ltd.
Introduction
Results
Delayed contrast enhancement (DCE) of the ischemictype and non-ischemic type is frequently detected by cardiac magnetic resonance imaging (cMRI) in patients after heart transplantation (HTX). The relation between different enhancement patterns and regional wall motion abnormalities (rWMA) is unknown.
Significant transplant coronary artery disease (TCAD) TCAD defined as coronary artery stenosis >75% was present in 6 patients (16%). Ischemic-type DCE was evident in 13 patients (34%) and 27 segments respectively. In 17 of 27 segments (63%) displaying ischemic-type DCE a rWMA was observed, in 10 of 27 (37%) segments contractility was visually normal. We found a significant correlation between segments with Ischemic-type DCE and segments with rWMA (r = 0.773, p < 0.0001). Nonischemic-type DCE was present 19 patients (50%) and 53 segments respectively. Only 4 (7.5%) of the affected 53 segments also showed rWMA. Consequently, no correlation was seen between segments with non-ischemic-type DCE and segments with rWMA (r = 0.068, p = 0.97). In 9 patients both types of DCE were observed, 6 of the 9 patients (67%) also displayed rWMA in a total of 21 segment. A total of 46 segments with rWMA were detected in 15 patients, whereof 4 patients did not show any type of DCE. Segmental analysis showed 25 of 46 segments (54%) with impaired contractility in the absence of any type of DCE. Of the remaining 21 segments with rWMA 17 segments (81%) displayed ischemic-type DCE; in only 4 segments with rWMA non-ischemic-type DCE was found.
Purpose We therefore sought to compare the presence of the two types of DCE and the association with rWMA in patients after HTX.
Methods 38 patients at a median interval of 81 months (range 12 to 201 months) after HTX underwent cMRI using a clinical 1.5 Tesla scanner for the assessment of DCE and regional left ventricular function. MR images were analysed following the 17-segment-model. Subendocardial and transmural DCE was classified as ischemic-type DCE. Intramural, spotted
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